Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. However, the duodenal location is less common. Nowadays, surgery is still the only curative approach for GIST. Numerous procedures can be performed to remove duodenal GIST. Some of these operations are extensive and require difficult reconstruction (like pancreaticoduodenectomy; PD). One of the options is a more limited intervention: segmental duodenectomy (SD). However, few studies have correlated the different surgical options with the oncological results.
A research article to be published on June 14, 2010 in the World Journal of Gastroenterology addresses this question. A Switzerland research group has conducted this study to evaluate the outcomes after SD and PD. They found that SD was a reliable and curative option for most duodenal GISTs, and was compatible with long-term disease-free survival (DFS). On the other hand, PD remains a good alternative for tumors in the vicinity of the pancreas.
In the present study, the authors report good oncological outcomes with long-term DFS in the SD group. Thus, whenever associated with clear surgical margins, SD is a reliable and curative option for most duodenal GISTs.
Reference: Buchs NC, Bucher P, Gervaz P, Ostermann S, Pugin F, Morel P. Segmental duodenectomy for gastrointestinal stromal tumor of the duodenum. World J Gastroenterol 2010; 16(22): 2788-2792
Correspondence to: Nicolas Christian Buchs, MD, Department of Surgery, University Hospital Geneva, 24 rue Michelidu- Crest, 1211, Geneva, Switzerland. firstname.lastname@example.org Telephone: +41-22-3723311 Fax: +41-22-3727707
About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2009 IF: 2.092. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.
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