Childhood cancer survival is associated with increased risk of long-term abnormalities in cardiac function, according to a report in the July 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
According to background in the article, childhood cancer survival rates have improved from 20 percent in the 1940s to roughly 70 to 80 percent currently. The authors also note that, "unfortunately, improved survival is accompanied by the occurrence of late treatment effects. Cardiovascular disease and cardiac mortality are among the most serious late effects." Additionally, the authors acknowledge, "several population-based studies observed a six- to eight-fold increased mortality owing to cardiovascular disease among childhood cancer survivors compared with the general population."
Helena J. van der Pal, M.D., from the Emma Children's Hospital/Academic Medical Center, Amsterdam, the Netherlands, and colleagues studied 601 childhood cancer survivors, surviving five years or more, focusing on previous diagnosis and treatment. The study was designed to "evaluate the prevalence and determinants of left ventricular dysfunction in a large cohort of long-term childhood cancer survivors treated with different potentially cardiotoxic therapies."
The authors found that abnormal cardiac function was observed during long-term follow-up (average duration of follow-up was 15.4 years) in 27 percent of childhood cancer survivors. It was most common in patients who received combined cancer treatments, but the authors found no evidence that sex, high-dose cyclophosphamide or ifosfamide (two cancer treatment drugs) were risk factors for cardiac dysfunction.
'The overall prevalence of 27 percent of childhood cancer survivors with cardiac dysfunction is alarmingly high in the young population," the authors note. "...These patients are expected to be at greater risk of developing clinical heart failure in the future."
"In conclusion, more than 25 percent of young adult childhood cancer survivors had subclinical [early stages, little to no symptoms] cardiac dysfunction at their first visit to the outpatient clinic for late effects of childhood cancer," the authors conclude. "Continued monitoring of all childhood cancer survivors treated with potentially cardiotoxic therapy with or without subclinical cardiac dysfunction is necessary to identify childhood cancer survivors who could possibly benefit from early treatment, which could avoid further deterioration of cardiac function."
(Arch Intern Med. 2010;170:1247-1255. Available pre-embargo to the media at www.jamamedia.org.)
Editor's Note: This study was supported by the Foundation of Pediatric Cancer Research, Amsterdam, the Netherlands. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.