Public Release: 

New reporting guidelines for genetic risk prediction studies: GRIPS Statement


This week PLoS Medicine publishes the Genetic RIsk Prediction Studies (GRIPS) Statement, a checklist and guidance to help strengthen the reporting of genetic risk prediction studies.

Because progress in gene discovery for complex diseases is fuelling interest in the application of genetic risk models for clinical and public health practice, the number of studies assessing predictive ability is steadily increasing, but the quality and completeness of reporting varies. The GRIPS Statement (and accompanying explanation document) provides guidance to enhance the transparency of study reporting, thereby improving the synthesis and application of information from multiple studies that might differ in design, conduct, or analysis.

In order to encourage dissemination, PLoS Medicine is co-publishing this article with Annals of Internal Medicine, BMJ, Circulation: Cardiovascular Genetics, European Journal of Clinical Investigation, European Journal of Epidemiology, European Journal of Human Genetics, Genetics in Medicine, Genome Medicine, and Journal of Clinical Epidemiology.


Funding: The workshop was sponsored by the US Centers for Disease Control and Prevention on behalf of the Human Genome Epidemiology Network (HuGENet). A. Cecile J.W. Janssens is financially supported by grants from the Erasmus University Medical Center Rotterdam, the Center for Medical Systems Biology in the framework of the Netherlands Genomics Initiative (NGI) and the VIDI grant of the Netherlands Organisation for Scientific Research (NWO). John P.A. Ioannidis: Tufts CTSI is supported by the National Institutes of Health/ National Center for Research Resources (UL1 RR025752). Opinions in this paper are those of the authors and do not necessarily represent the official position or policies of the Tufts CTSI. Julian Little holds a Canada Research Chair in Human Genome Epidemiology. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

Competing Interests: John P. A. Ioannidis is a member of the PLoS Medicine Editorial Board.

Citation: Janssens ACJW, Ioannidis JPA, van Duijn CM, Little J, Khoury MJ, et al. (2011) Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement. PLoS Med 8(3): e1000420. doi:10.1371/journal.pmed.1000420



Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.