PITTSBURGH, March 31 – More than twice as many lungs and nearly 50 percent more kidneys could be recovered for transplant operations if intensive care physicians were to work with organ procurement organization (OPO) coordinators to monitor and manage donor bodies after brain death has occurred, according to an analysis by UPMC and University of Pittsburgh School of Medicine physicians that is now in the online version of the American Journal of Transplantation.
After a patient who has consented to be an organ donor is declared brain dead, an OPO coordinator takes over medical management and intensive care unit (ICU) physicians typically are no longer involved, explained lead author Kai Singbartl, M.D., assistant professor of critical care medicine at the University of Pittsburgh School of Medicine and a UPMC intensivist. The OPO coordinators follow established protocols to maintain tissues and organs for eventual transplant.
"Our analysis shows an intensivist at the donor's bedside who aids and advises the OPO coordinator can result in a greater likelihood of recovering organs that are deemed acceptable for transplant, which would mean that each donor could help us save more lives, " he said. "The gap between the number of people on waiting lists and the number of available organs is growing, so measures that increase the pool of organs are very much needed."
In 2008, UPMC Presbyterian implemented an intensivist-led organ donor support team (ODST) approach in which after a potential organ donor was declared brain dead, one of six dedicated intensivists, who did not provide care for the donor prior to death, joined the OPO coordinator at the bedside. Standard protocols were supported by physician interventions, such as adjustments to optimize oxygenation and meticulously balance blood pressure and flow, fluids and other bodily functions to optimize the likelihood of sustaining as many organs as possible for transplant.
"We would care for donors for a few hours or up to a day, depending on medical needs and other factors," Dr. Singbartl said. "The number of donors in our study is not large enough to determine whether a particular medical intervention played a key role, but it's very clear from our experience that this team approach did make a difference."
Data from adult brain dead donors between July 1, 2008 and June 30, 2009 was compared to data from July 1, 2007 to June 30, 2008, before the ODST approach had been used. In the earlier time period, 31 percent, or 66 out of 210 potentially available organs were transplanted. In the ODST period, 44 percent, or 113 out of 258 potentially available organs were transplanted.
Most of the increase after implementation of the ODST approach was due to a more than 200% increase in transplanted lungs and a nearly 50% percent increase in transplanted kidneys. Heart and liver transplant rates did not change significantly.
"Conversion of medically unsuitable donors into actual donors, better resuscitation of unstable donors, optimization of organ function, and improved communication between OPO staff, ICU team and transplant surgeons" or the combination of these factors likely contributed to success and should be further evaluated, the researchers said.
Co-authors include Raghavan Murugan, M.D., A. Murat Kaynar, M.D., David W. Crippen, M.D., Richard L. Simmons, M.D., and Joseph M. Darby, M.D., Departments of Critical Care Medicine and Surgery, University of Pittsburgh School of Medicine; and Kurt Shutterly, R.N., and Susan A. Stuart, R.N., Center for Organ Recovery and Education, Pittsburgh, Pa.
About UPMC
UPMC is an $8 billion global health enterprise with almost 50,000 employees headquartered in Pittsburgh, Pa., and is transforming health care by integrating 20 hospitals, 400 doctors' offices and outpatient sites, a health insurance services division, and international and commercial services. Affiliated with the University of Pittsburgh Schools of the Health Sciences, UPMC is redefining health care by using innovative science, technology and medicine to invent new models of accountable, cost-efficient and patient-centered care. For more information on how UPMC is taking medicine from where it is to where it needs to be, go to www.upmc.com.
About the University of Pittsburgh School of Medicine
As one of the nation's leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1997 and now ranks fifth in the nation, according to NIH data for 2008 (the most recent year for which the data are final).
Likewise, the School of Medicine is equally committed to advancing the quality and strength of its medical and graduate education programs, for which it is recognized as an innovative leader, and to training highly skilled, compassionate clinicians and creative scientists well-equipped to engage in world-class research. The School of Medicine is the academic partner of UPMC, which has collaborated with the University to raise the standard of medical excellence in Pittsburgh and to position health care as a driving force behind the region's economy. For more information about the School of Medicine, see www.medschool.pitt.edu.
Journal
American Journal of Transplantation