Many people tout the beneficial effects of probiotics in preventing and/or treating several intestinal diseases, including ulcerative colitis. Although there have been few, if any, good clinical studies evaluating the clinical efficacy of probiotics, preclinical data suggest that probiotics and approaches utilizing probiotic-derived products could be effective therapies for acute and chronic gastrointestinal disorders. In this context, a team of researchers, led by Fang Yan, at Vanderbilt University Medical Center, Nashville, have now identified a new probiotic bacteria–derived soluble protein that can protect intestinal cells from inflammation and injury and unraveled its mechanism of action. Importantly, specific delivery of the protein (p40) to the colon provided therapeutic and prophylactic protection in several mouse models of colitis. The authors suggest that their data provide rationale for the development of probiotic-derived proteins as reagents for preventing and/or treating ulcerative intestinal inflammatory disorders.
In an accompanying commentary, Fayez Ghishan and Pawel Kiela, at the University of Arizona, Tucson, concur with this position, although they caution that further work in humans is needed.
TITLE: Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism
AUTHOR CONTACT:
Fang Yan
Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Phone: 615.343.5021; Fax: 615.343.5323; E-mail: fang.yan@vanderbilt.edu.
View this article at: http://www.jci.org/articles/view/44031?key=24d663bbebde11d8c23d
ACCOMPANYING COMMENTARY
TITLE: From probiotics to therapeutics: another step forward?
AUTHOR CONTACT:
Fayez K. Ghishan
University of Arizona, Tucson, Arizona, USA.
Phone: 520.626.5170; Fax: 520.626.7176; E-mail: fghishan@peds.arizona.edu.
View this article at: http://www.jci.org/articles/view/58025?key=9172d5ef2e96a5eda4f0
Journal
Journal of Clinical Investigation