Public Release: 

Living alone associated with higher risk of mortality, cardiovascular death

The JAMA Network Journals

CHICAGO - Living alone was associated with an increased risk of death and cardiovascular death in an international study of stable outpatients at risk of or with arterial vascular disease (such as coronary disease or peripheral vascular disease), according to a report published Online First by Archives of Internal Medicine, a JAMA Network publication.

Social isolation may be associated with poor health consequences, and the risk associated with living alone is relevant because about 1 in 7 American adults lives alone. Epidemiological evidence suggests that social isolation may alter neurohormonal-mediated emotional stress, influence health behavior and effect access to health care, which may result in association with or acquisition of, cardiovascular risk, according to the study background.

Jacob A. Udell, M.D., M.P.H., of Brigham and Women's Hospital, Harvard Medical School, Boston, and colleagues examined whether living alone was associated with increased mortality and cardiovascular (CV) risk in the global REduction of Atherothrombosis for Continued Health (REACH) Registry. Among 44,573 REACH participants, 8,594 (19 percent) lived alone.

Living alone was associated with higher four-year mortality (14.1 percent vs. 11.1 percent) and cardiovascular death (8.6 percent vs. 6.8 percent), according to the study results.

Based on age, living alone was associated with an increased risk of death among those patients 45 to 65 years old compared with those living with others (7.7 percent vs. 5.7 percent) , and among those participants 66 to 80 years old (13.2 percent vs. 12.3 percent). However, among patients older than 80 years, living alone was not associated with an increased risk of mortality compared with those living with others (24.6 percent vs. 28.4 percent), the results indicate.

"In conclusion, living alone was independently associated with an increased risk of mortality and CV death in an international cohort of stable middle-aged outpatients with or at risk of atherothrombosis," the authors conclude. "Younger individuals who live alone may have a less favorable course than all but the most elderly individuals following development of CV disease, and this observation warrants confirmation in further studies."


(Arch Intern Med. Published online June 18, 2012. doi:10.1001/archinternmed.2012.2782. Available pre-embargo to the media at

Editor's Note: Authors offered numerous financial disclosures, including work as a consultant or on an advisory board, grants and salary funding. The REACH Registry is sponsored by sanofi-aventis, Bristol-Myers Squibb, and the Waksman Foundation (Tokyo, Japan). The REACH Registry is endorsed by the World Heart Federation. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

To contact corresponding author Deepak L. Bhatt, M.D., M.P.H., call Diane Keefe at 857-203-5879 or email

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.