Men and women with autism spectrum conditions (ASC) may show subtle but significant differences in the cognitive functions impacted by the condition, according to new research published Oct 17 by Meng-Chuan Lai and colleagues from the Autism Research Centre at the University of Cambridge, UK in the open access journal PLOS ONE.
Though individuals with autism show sex-specific differences in serum biomarkers, genetics and brain anatomy, little is known about any sex-dependent differences in cognition caused by ASC. Following their previous report on behavioral sex differences in adults with ASC (also published in PLOS ONE, see (http://dx.
According to the authors, their results suggest that the severity with which certain cognitive functions are affected by autism may be dependent on sex, and has implications for assessment and intervention of ASC.
"What we know about males with ASC should not be assumed to generalize to females", said Dr. Lai. "Their similarities and differences need to be investigated systematically in autism research."
Citation: Lai M-C, Lombardo MV, Ruigrok ANV, Chakrabarti B, Wheelwright SJ, et al. (2012) Cognition in Males and Females with Autism: Similarities and Differences. PLoS ONE 7(10): e47198. doi:10.1371/journal.pone.0047198
Financial Disclosure: The project was funded by the United Kingdom Medical Research Council (GO 400061, http://www.
Competing Interest Statement: The authors have declared that no competing interests exist.
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