Public Release: 

International collaboration seeks to develop noninvasive quantum electron microscope

Gordon & Betty Moore Foundation

Moving closer to creating a microscope that can peer through atoms and molecules without disturbing them, leading physics researchers have joined together with support from the Gordon and Betty Moore Foundation to launch an international collaboration to lay the groundwork for the development of a novel quantum electron microscope.

The $4 million, three-and-a-half-year effort will be spearheaded by Dr. Mark Kasevich at Stanford, Dr. Peter Hommelhoff at The Max Planck Institute of Quantum Optics, Drs. Fatih Yanik and Karl Berggren at Massachusetts Institute of Technology and Dr. Pieter Kruit at Delft University of Technology in the Netherlands. The research groups will work together to demonstrate interaction-free measurements with electrons, which, if successful, would form the basic principles for future development of an electron microscope with the potential to yield important discoveries in many areas of science.

The theory was first proposed by Dr. Yanik's team at MIT in a paper for Physical Review Rapid Communications in October 2009 (Phys Rev A 80, 040902(R) 2009). This new international collaboration will begin testing the theory, making significant strides towards its realization.

"The Gordon and Betty Moore Foundation's Science Program seeks to support high-impact scientific research, and we see this project as exactly that kind of opportunity," said Vicki Chandler, chief program officer for Science at Moore. "We expect that the work this team is doing will enable exciting new science through technology, and the scientists will acquire fundamental new knowledge in quantum mechanics and manipulation of electrons."

Although light and electron microscopes have shaped our modern understanding of biology--with discoveries as fundamental as the eukaryotic cell, bacteria and viruses, to name just a few--major barriers to answering fundamental biological questions remain, including the inability to visualize molecules interacting within living cells. The light microscope can image living things, but not at molecular resolution. The electron microscope, on the other hand, can image molecules and atoms, but cannot be used to study live samples due to the intense radiation the sample is exposed to. A quantum electron microscope, however, promises to overcome these deficiencies in current imaging technologies by allowing scientists to peer into living cells at molecular resolution without radiation damage, dramatically expanding our understanding of how cells work.

Recent advances in the quantum-level control of electrons open the door to development of an electron microscope based on non-destructive quantum measurement principles. These instruments may enable real-time, non-destructive imaging of biological samples. A three-year, coordinated program to develop the foundational ideas in support of this technology will involve each university team taking parallel but distinct technical and scientific approaches.

Throughout its history, science has relied on technical advances and surges in new knowledge that have offered researchers unexpected breakthroughs--and new questions. The quantum electron microscope will offer transformational new approaches, with the potential for an enduring impact on fundamental physics, engineering and biology.


About TU Delft

Delft University of Technology was founded in 1842 and with its 3300 scientists and 19000 students from 100 nationalities is still the largest in the Netherlands. Ranked among the top universities of technology in the world TU Delft's research and education are backed by outstanding facilities in areas such as nanotechnology. Activities in the Faculty of Applied Sciences range from fundamental research on life at the nanoscale to pursuing innovations in physics instrumentation in close cooperation with industry.

About the Research Laboratory of Electronics

The Research Laboratory of Electronics (RLE), MIT's leading entrepreneurial interdisciplinary research organization, provides a collaborative and vibrant intellectual community for more than 600 researchers. Through RLE faculty, the Laboratory has made significant discoveries over the years in various areas including Optical Coherence Tomography (OCT) and High-Definition Television (HDTV), and has celebrated achievements such as a Physics Nobel Prize win and the emergence of Bose Corporation. Originally rooted in the exploration of Airborne Radar, RLE aims to create a stimulating and supportive environment for visionary and diverse research, and strategically deploys resources to achieve excellence in research and education, and to support translation of engineering innovations to application technologies that are relevant to today and critical to tomorrow.

About the Max Planck Institute of Quantum Optics

Research at the Max Planck Institute of Quantum Optics explores the interaction of light and quantum systems, exploiting the two extreme regimes of the wave-particle duality of light and matter. For more information, please see

About Stanford Physics

Located in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing our students for leadership in today's complex world. Stanford Physics is a teaching and research department. Undergraduates, graduate students and postdoctoral fellows are mentored and involved in research in astrophysics, cosmology, particle physics, atomic and laser physics, and condensed matter physics. The department enjoys close connections to Applied Physics and departments at SLAC.

About the Gordon and Betty Moore Foundation

The Gordon and Betty Moore Foundation, established in 2000, seeks to advance environmental conservation, patient care and scientific research. Believing in the inherent value of science and the sense of awe that discovery inspires, the Foundation's Science Program invests in the development of new technologies, supports the world's top scientists and brings together partnerships with the aim to transform, push the boundaries of--and even create--entire fields of scientific research. For more information, please visit

Prof. Pieter Kruit
Delft University of Technology
Lorentzweg 1, 2628 CJ Delft
The Netherlands
Phone +31 (0)15-2785197

Prof. Mehmet Fatih Yanik
Massachusetts Institute of Technology
Phone: 617-253-1583
E-mail: yanik@MIT.EDU

Prof. Karl Berggren
Massachusetts Institute of Technology
Phone: 617.324.0272
E-mail: berggren@MIT.EDU

Prof. Peter Hommelhoff
Max-Planck-Institute of Quantum Optics
Phone: +49 89 32905 265

Prof. Mark Kasevich
Physics Dept.
Stanford University
Phone: 650-723-4356

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