Although an intravenous fluid that paramedics in Japan often give to patients in cardiac arrest before they reach hospital may help restore circulation, it may also be linked to reduced survival with minimal neurological or physical damage one month later, according to a study from Japan published in this week's PLOS Medicine.
In Japan, intravenous fluid loading with lactated Ringer's solution (a mixture of salts and sodium lactate) is included in resuscitation guidelines for patients who have a cardiac arrest out of hospital. In order to investigate outcomes associated with this practice, Japanese researchers, led by Akihito Hagihara from the Kyushu University Graduate School of Medicine, analysed national information from 2005 to 2009 on more than a half million patients experiencing a cardiac arrest out-of-hospital and then examined their subsequent health outcomes one month later.
The authors found that when other factors such as age, sex, and time taken for help to arrive were taken into account, the pre-hospital use of lactated Ringer's solution was linked to a slightly increased chance (1.2) of return of spontaneous circulation before arrival at hospital but with a decreased chance (0.7) of survival with minimal neurological or physical impairment one month later. However, among all patients, the pre-hospital use of lactated Ringer's solution had no effect on overall survival at one month.
Although these findings may have important clinical implications, the authors make clear that these results will need to be confirmed in other studies before changing clinical guidelines. Their study did not have information on the treatment that patients received once they reached hospital, which may have influenced the results.
The authors say: "We found that prehospital IV loading with lactated Ringer's solution was independently associated with a decreased likelihood of 1-month survival with minimal neurological or physical impairment."
They continue: "Prehospital IV loading with lactated Ringer's solution was associated with an increased likelihood of return of spontaneous circulation before hospital arrival, while 1-month survival varied depending on the analysis."
The authors add: "Our findings should be verified by studies that include data on in-hospital resuscitation."
They conclude: "Future studies will need to determine whether administration of fluids other than lactated Ringer's solution is associated with beneficial outcomes."
Funding: This study was partly supported by a sponsored research contract with the Fire and Disaster Management Agency of the Ministry of Internal Affairs and Communications. No funding was required or used during the writing of this paper, none of the authors were salaried during the time of writing, and no funders had any role in the study design, data collection, analysis, decision to publish or preparation of the manuscript.
Competing interests: The article's contents are solely the responsibility of the authors and do not necessarily represent the official views of the Fire and Disaster Management Agency, Ministry of Internal Affairs and Communications, or Kyushu University. The authors have declared that no competing interests exist.
Citation: Hagihara A, Hasegawa M, Abe T, Wakata Y, Nagata T, et al. (2013) Prehospital Lactated Ringer's Solution Treatment and Survival in Out-of-Hospital Cardiac Arrest: A Prospective Cohort Analysis. PLoS Med 10(2): e1001394. doi:10.1371/journal.pmed.1001394
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Kyushu University Graduate School of Medicine
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