Reston, Va. - While amyloid imaging may now be most associated with detecting plaques in the brain, it has the potential to change the way cardiac amyloidosis is diagnosed. According to first-of-its-kind research published in the February issue of The Journal of Nuclear Medicine, positron emission tomography (PET) with 11C-PIB can positively visualize amyloid deposits in the heart. Currently there is no noninvasive test available for specific diagnosis.
Cardiac amyloidosis is a deadly disorder caused by abnormal amyloid deposits in the heart tissue. Early diagnosis before structural change to the heart tissue has occurred is important for disease prognosis and for treatment monitoring. Currently echocardiography is the mainstay of imaging in cardiac amyloidosis; a cardiac biopsy is used to confirm diagnosis.
"Imaging with 11C-PIB provides a non-invasive and specific means of showing distribution of amyloid in an organ. This gives a unique opportunity to follow and monitor therapy, as amyloid deposits in the heart should decrease with successful therapy," said Gunnar Antoni, PhD, lead author of the study "In Vivo Visualization of Amyloid Deposits in the Heart with 11C-PIB and PET."
The study included 10 patients diagnosed with cardiac amyloidosis and five healthy individuals. PET/computed tomography (CT) with 11C-PIB was used to visualize amyloid deposits in the heart and with 11C-acetate to measure myocardial blood flow.
Uptake of 11C-PIB was measured 15-25 minutes after injection. Obvious uptake of 11C-PIB was noted in the left ventricle wall of all patients with cardiac amyloidosis, while no uptake was seen in the healthy volunteers. In half of the patients, 11C-PIB was also detected in the right ventricle wall, and nine of the patients had signs of reversible uptake, with a maximum concentration at 10-15 minutes after injection. Myocardial blood flow was significantly lower in patients with cardiac amyloidosis; however, no significant correlation between myocardial blood flow and 11C-PIB uptake was found.
"This study emphasizes the strength of molecular imaging for detecting an underlying and significant molecular aberration in a disease that presents with unspecific symptoms and signs," noted Antoni. "The potential for molecular imaging to provide valuable information for other diseases is of great value to the field of medicine."
Authors of the article "In Vivo Visualization of Amyloid Deposits in the Heart with 11C-PIB and PET" include Gunnar Antoni, Platform for Preclinical PET, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden, and PET Centre, Uppsala University Hospital, Uppsala, Sweden; Mark Lubberink, Tanja Kero, Cecilia Wassberg and Jens Sörensen PET Centre, Uppsala University Hospital, Uppsala, Sweden, and Nuclear Medicine and PET, Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Uppsala, Sweden; Sergio Estrada, Platform for Preclinical PET, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden; Jan Axelsson, Radiation Physics, Department of Radiation Sciences, Umeå University, Umeå, Sweden; Kristina Carlson and Sara Rosengren, Department of Hematology, Uppsala University Hospital; Uppsala, Sweden; Lars Lindsjö, PET Centre, Uppsala University Hospital, Uppsala, Sweden; Bengt Långström; Department of Biochemistry and Organic Chemistry, Uppsala University, Uppsala, Sweden, Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Imperial College, London, United Kingdom, and PET and Cyclotron Unit, Department of Nuclear Medicine, Institute of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark; Sven-Olof Granstam, Ola Vedin and Gerhard Wikström, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; and Per Westermark, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.