Adrenocorticotropic hormone is recommended worldwide as an initial therapy for infantile spasms. However, infantile spasms in about 50% of children cannot be fully controlled by adrenocorticotropic hormone monotherapy, seizures recur in 33% of patients who initially respond to adrenocorticotropic hormone monotherapy, and side effects are relatively common during adrenocorticotropic hormone treatment. Feiyong Jia and colleagues from the First Hospital of Jilin University used combined therapy with adrenocorticotropic hormone, topiramate, vitamin B6, and immunoglobulin in 51 cases of infantile spasms, and they found that the initial polytherapy with adrenocorticotropic hormone, topiramate, vitamin B6, and immunoglobulin effectively improves the prognosis of infantile spasms, and its effects were superior in cryptogenic children to symptomatic children. These findings were published in the Neural Regeneration Research (Vol. 8, No. 17, 2013).
Article: " An effective initial polytherapy for children with West syndrome," by Feiyong Jia1, Huiyi Jiang1, Lin Du1, Ning Li1, Ji Sun1, Chunbo Niu2 (1 Department of Pediatric Neurorehabilitation, Second Part of First Hospital, Jilin University, Changchun 130031, Jilin Province, China; 2 Department of Pathology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China)
Jia FY, Jiang HY, Du L, Li N, Sun J, Niu CB. An effective initial polytherapy for children with West syndrome. Neural Regen Res. 2013;8(17):1623-1630.