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Optimal irradiation dose and time window of local X-ray for spinal cord injury

Neural Regeneration Research


IMAGE: After seven days of X-irradiation, syringomyelia and glial scar (arrow) were reduced in the center of spinal cord injury. view more

Credit: Neural Regeneration Research

The glial scar is the main inhibitor of axon regeneration and functional recovery in the central nervous system. Appropriate dose X-ray irradiation has been shown to inhibit the formation of glial cells, thereby promoting axonal regeneration. In addition, X-rays militate against the death and degeneration of neurons, and improve the recovery of locomotor function following spinal cord injury. However, the optimal treatment time window and dose of X-irradiation for spinal cord injury is still unknown. Prof. Shiqing Feng and colleagues from Tianjin Medical University have verified that X-irradiation at a dose of 8 Gy can inhibit glial scar formation at the injury site and alleviate the inflammatory reaction; day 7 post injury may be the optimal time window for topical X-irradiation. These findings were published in the Neural Regeneration Research (Vol. 8, No. 17, 2013).


Article: "X-irradiation for inhibiting glial scar formation in injured spinal cord," by Guangzhi Ning1, Renhui Chen2, Yulin Li1, Qiang Wu1, Qiuli Wu1, Yan Li1, Shiqing Feng1 (1 Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, China; 2 Department of Orthopedics, Tianjin 4th Central Hospital, Tianjin 300140, China)

Ning GZ, Chen RH, Li YL, Wu Q, Wu QL, Li Y, Feng SQ. X-irradiation for inhibiting glial scar formation in injured spinal cord. Neural Regen Res. 2013;8(17):1582-1589.

Meng Zhao

Neural Regeneration Research:

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