Public Release: 

Understanding the role of IKACh in cardiac function

Rockefeller University Press


IMAGE: This is a close-up view of cardiac pacemaker cells within the sinoatrial node. A study in The Journal of General Physiology shows a novel role for IKACh in cardiac pacemaker... view more

Credit: Mesirca et al., 2013

Researchers have uncovered a previously unknown role for the acetylcholine-activated inward-rectifying potassium current (IKACh) in cardiac pacemaker activity and heart rate regulation, according to a study in The Journal of General Physiology.

The heart rate increases in response to fear or exercise, when the body's sympathetic nervous system activates the "fight or flight" stress response. After sympathetic stimulation, the heart rate is brought back to normal by the parasympathetic nervous system, which regulates the body at rest. Parasympathetic regulation of the heart rate is initiated when acetylcholine released from the vagus nerve spurs a chain of events that activate IKACh in the sinoatrial node--the pacemaker of the heart--to reduce the heart rate. However, the precise role of IKACh is not fully understood.

To find out more, researchers used mice lacking a specific gene required for IKACh to investigate the consequences of its loss. The mice showed a moderate increase in resting heart rate compared with that in a control group, and they displayed a significant delay in the recovery of resting heart rate after stress, exercise, or administration of a drug that simulated activation of the fight or flight response. The results indicate that IKACh plays a critical role in both of these parasympathetic cardiac functions.


About The Journal of General Physiology

Founded in 1918, The Journal of General Physiology (JGP) is published by The Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editor. JGP content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works and third parties may reuse the content for non-commercial purposes under a creative commons license. For more information, please visit

Mesirca, P., et al. 2013. J. Gen. Physiol. doi:10.1085/jgp.201310996

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.