image: Amplified bands of hypoxia-inducible factor-1α and heme oxygenase-1 mRNA appeared in the frontal cortex of chronic cerebral ischemic rats at three, six, and nine weeks. Cilostazol reduced hypoxia-inducible factor-1α and heme oxygenase-1 expression and activity. view more
Credit: <i>Neural Regeneration Research</i>
Hypoxia-inducible factor-1 and its specific target gene heme oxygenase-1 are involved in acute cerebral ischemia. However, very few studies have examined in detail the changes in the hypoxia-inducible factor-1/heme oxygenase-1 signaling pathway in chronic cerebral ischemia. Prof. Zhongxin Xu and team from China-Japan Friendship Hospital, Jilin University clarified that the hypoxia-inducible factor-1/heme oxygenase-1 signaling pathway is activated following chronic cerebral ischemia and involved in the development of cognitive impairment induced by chronic cerebral ischemia. Additionally, cilostazol treatment can decrease hypoxia-inducible factor-1α and heme oxygenase-1 expression levels, and protect against cognitive impairment induced by chronic cerebral ischemic injury through an anti-apoptotic mechanism. These findings are published in the Neural Regeneration Research (Vol. 8, No. 19, 2013).
Article: " Changes of hypoxia-inducible factor-1 signaling and the effect of cilostazol in chronic cerebral ischemia," by Han Chen1, 2, Aixuan Wei1, 3, Jinting He1, Ming Yu4, Jing Mang1, Zhongxin Xu1 (1 Department of Neurology, China-Japan Friendship Hospital, Jilin University, Changchun 130012, Jilin Province, China; 2 Department of Neurology, Chang Chun Central Hospital, Changchun 130051, Jilin Province, China; 3 Department of Neurology, Jilin City Central Hospital, Jilin 132011, Jilin Province, China; 4 Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China)
Chen H, Wei AX, He JT, Yu M, Mang J, Xu ZX. Changes of hypoxia-inducible factor-1 signaling and the effect of cilostazol in chronic cerebral ischemia. Neural Regen Res. 2013;8(19):1803-1813.
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Journal
Neural Regeneration Research