Short-term hearing loss can cause long-term problem

BOSTON (Sept. 30, 2013) — Short-term hearing loss during childhood may lead to persistent hearing deficits, long after basic auditory sensitivity has returned to normal. The processing of sound in the brain is shaped by early experience. New research from Massachusetts Eye and Ear has identified two critical periods occurring shortly after hearing onset that regulate how sounds from each ear are fused into a coherent representation in the brain. Their research is described in Nature Communications.

Hearing scientist Daniel Polley, Ph.D., an investigator at Massachusetts Eye and Ear/Harvard Medical School's Eaton-Peabody Laboratories of Auditory Physiology and collaborators found by inducing a brief, reversible hearing loss at key milestones in cortical development, they identified two critical periods occurring after hearing onset that regulate the maturation of coordinated binaural sound representations. Their work could eventually lead to a better understanding of which periods in a child's development are most crucial to maintain hearing.

Degraded sensory experience during critical periods of childhood development can have detrimental effects on the brain and behavior. In the classic example, a condition called amblyopia (also known as lazy eye) can arise when balanced visual signals are not transmitted from each eye to the brain during a critical period for visual cortex development. In this study, researchers set out to determine how temporary disruption of hearing at precise times in development affect the ability for the brain to hear once hearing is restored.

"The goal of this study was to mimic the moderate, short-term hearing loss that can accompany ear infections in human infants and then study how and when the encoding of auditory signals was disrupted in the brains of developing mice."

Much like starting up a computer, the brain "boots" itself during development beginning with the basic firmware and culminating with higher-level software elements. Unlike a computer, the brain relies on experience from the surrounding sensory environment to complete its startup process. If sensory experience is degraded during these critical periods in early life, as would occur with a visual cataract or conductive hearing loss that can accompany an ear infection, the brain's representation of the sensory world can be distorted in a specific and enduring way, even after the physical deficit in the eye or ear has been corrected. In this study, researchers found that creating a temporary hearing loss one day after hearing begun disrupted the basic alignment of sound frequency selectivity in the mouse cortex, whereas the same manipulation initiated just a few days later interfered with the neural computation of loudness differences between the ears.

"These findings demonstrate that brief bouts of asymmetric hearing loss during very specific points in postnatal development can have a lasting effect on brain circuits that compare and integrate the sound waves that enter each ear," said Dr. Polly. "According to pediatric audiology studies and the latest U.S. census data, approximately 12% of children (or 2.6 million children in the United States alone) will experience at least one bout of otitis media severe enough to cause a brief, mild conductive hearing loss before reaching five years of age. Though our study was conducted in an animal model, these data support a growing body of work that underscores the importance of minimizing hearing loss or excessive environmental noise for healthy infant brain development."

About Dr. Daniel Polley: Dr. Daniel Polley is a principal investigator at the Eaton-Peabody Laboratories of Auditory Physiology at the Massachusetts Eye and Ear in Boston, Mass., where the focus of his research is auditory cortex development and plasticity. Dr. Polley received a B.A. in Psychology from the University of Richmond (1996), a Ph.D. in Biological Sciences from the University of California, Irvine (2001) and completed a Postdoctoral Fellowship at the University of California, San Francisco (2005). He was formerly an Assistant Professor at Vanderbilt University.

This work was funded by National Institutes of Health Grants R01 DC009836, P30 DC5029, and a Howard Hughes Medical Institute International Student Research Fellowship. A full list of authors and their affiliations is available in the pdf.

Mass. Eye and Ear clinicians and scientists are driven by a mission to find cures for blindness, deafness and diseases of the head and neck. After uniting with Schepens Eye Research Institute Mass. Eye and Ear in Boston became the world's largest vision and hearing research center, offering hope and healing to patients everywhere through discovery and innovation. Mass. Eye and Ear is a Harvard Medical School teaching hospital and trains future medical leaders in ophthalmology and otolaryngology, through residency as well as clinical and research fellowships. Internationally acclaimed since its founding in 1824, Mass. Eye and Ear employs full-time, board-certified physicians who offer high-quality and affordable specialty care that ranges from the routine to the very complex. U.S. News & World Report's "Best Hospitals Survey" has consistently ranked the Mass. Eye and Ear Departments of Otolaryngology and Ophthalmology as top five in the nation.