Spider venoms are usually toxic when injected into prey, but a new protein discovered in the venom of Australian tarantulas can also kill prey insects that consume the venom orally. The protein is strongly insecticidal to the cotton bollworm, an important agricultural pest, according to research published September 11 in the open access journal PLOS ONE by Glenn King and Maggie Hardy from the Institute of Molecular Bioscience at the University of Queensland, Australia, and colleagues from other institutions.
The small protein, named orally active insecticidal peptide-1 (OAIP-1), was found to be highly toxic to insects that consumed it, with potency similar to that of the synthetic insecticide imidacloprid. Cotton bollworm, a pest that attacks crop plants, was more sensitive to OAIP-1 than termites and mealworms, which attack stored grains.
These and other insect pests reduce global crop yields by 10-14% annually and damage 9-20% of stored food crops, and several species are resistant to available insecticides. Isolated peptides from the venom of spiders or other venomous insectivorous animals, such as centipedes and scorpions, may have the potential to serve as bioinsecticides. Alternately, the authors suggest the genes encoding these peptides could be used to engineer insect-resistant plants or enhance the efficacy of microbes that attack insect pests. King elaborates, "The breakthrough discovery that spider toxins can have oral activity has implications not only for their use as bioinsecticides, but also for spider-venom peptides that are being considered for therapeutic use."
Citation: Hardy MC, Daly NL, Mobli M, Morales RAV, King GF (2013) Isolation of an Orally Active Insecticidal Toxin from the Venom of an Australian Tarantula. PLoS ONE 8(9): e73136. doi:10.1371/journal.pone.0073136
Financial Disclosure: The authors acknowledge financial support from the Australian Research Council (Discovery Grant DP0774245 to G.F.K.). M.C.H. was supported by a University of Queensland Research Scholarship and an Australian Government International Postgraduate Research Scholarship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interest Statement: The authors have declared that no competing interests exist.
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