Amyloid β-peptide, a major component of senile plaques in Alzheimer's disease, has been impli-cated in neuronal cell death and cognitive impairment. Recently, studies have shown that the pathogenesis of cerebral ischemia is closely linked with Alzheimer's disease. According to a study, administration of amyloid β-peptide could further aggravate impairments to learning and memory and neuronal cell death in the hippocampus of rats subjected to cerebral ischemia-reperfusion injury. The synergistic effect of amyloid β-peptide and cerebral ischemia-reperfusion injury exacerbated nerve damage by inducing glycogen synthase kinase 3β and protein phosphatase 2A activity, which resulted in the phosphorylation of tau protein. This study by Dr. Bo Song and team from Research Center of Stem Cells and Regenerative Medicine, School of Medicine, Tsinghua University, China was published in the Neural Regeneration Research (Vol. 8, No. 26, 2013)
Article: " Amyloid beta-peptide worsens cognitive impairment following cerebral ischemia-reperfusion injury," by Bo Song1, 2, Qiang Ao3, Ying Niu2, Qin Shen1, Huancong Zuo3, Xiufang Zhang2, Yandao Gong2 (1 Research Center of Stem Cells and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China; 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China; 3 Institute of Neurology Disorders, Yuquan Hospital, Tsinghua University, Beijing 100049, China)
Song B, Ao Q, Niu Y, Shen Q, Zuo HC, Zhang XF, Gong YD. Amyloid beta-peptide worsens cognitive impairment following cerebral ischemia-reperfusion injury. Neural Regen Res. 2013;8(26):2449-2457.