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Does zinc supplementation reduce aluminum-induced neurotoxicity?

Neural Regeneration Research


IMAGE: Pyknotic nuclei and prominent perineuronal spaces in the hippocampus of rats are visible in the group given the 50 mg/kg zinc supplement (hematoxylin-eosin staining, Leica, × 400). view more

Credit: Neural Regeneration Research

Studies have shown that aluminum neurotoxicity can likely affect learning and memory function, and a diet containing 100-200 mg/kg zinc is adequate for maintaining learning and memory function in rats. Previous findings by Dr. Hao Lu and coworkers from Academy of Military Medical Sciences, China showed that male Wistar rats after treatment with aluminum chloride at a dose of 300 mg/kg daily for 7 weeks exhibited decreased acetylcholinesterase activity and enhanced lipid peroxidation in the cerebrum, appearing to have neurotoxic performance. A new study from these researchers further evaluated the effect of zinc supplementation on aluminum-induced neurotoxicity, and found zinc supplementation exhibited an antioxidant capacity. This study, published in the Neural Regeneration Research (Vol. 8, No. 29, 2013), can provide new targets and approaches for prevention and treatment of central nervous system diseases and open up new ideas for in-depth study of the relationship between zinc and brain function.


Article: " Optimal dose of zinc supplementation for preventing aluminum-induced neurotoxicity in rats," by Hao Lu1, 2, Jianyang Hu3, Jing Li2, 4, Wei Pang2, Yandan Hu1, 2, Hongpeng Yang2, Wenjie Li4, Chengyu Huang1, Mingman Zhang3, Yugang Jiang2 (1 Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan Province, China; 2 Department of Nutrition, Institute of Health & Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China; 3 Department of Hepatobiliary Surgery, Children's Hospital, Chongqing Medical University, Chongqing 400014, China; 4 Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China)

Lu H, Hu JY, Li J, Pang W, Hu YD, Yang HP, Li WJ, Huang CY, Zhang MM, Jiang YG. Optimal dose of zinc supplementation for preventing aluminum-induced neurotoxicity in rats. Neural Regen Res. 2013;8(29):2754-2762.


Meng Zhao
Neural Regeneration Research

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