The N-methyl-D-aspartic acid (NMDA) receptor dysfunction in the brain of aged animals has been shown. In older rodents, N-methyl-D-aspartate receptor 2B subunit gene expression declines significantly associated with memory impairment. To further reveal this process, Dr. Chunxia Li and colleagues from East China Normal University, China analyzed gene expression profiles in the neocortex of aged Tg mice. Pathway and signal-net analyses identified multiple pathways altered in the transgenic mice. Further signal-net analysis highlighted the P53 and insulin-like growth factor pathways as key regulatory pathways. Meanwhile, these results were verified deeply by fluorescent quantitative PCR Technique and western blot. These experimental findings, published in the Neural Regeneration Research (Vol. 8, No. 29, 2013), provide new insight into understanding the molecular mechanisms of NR2B regulated age-related memory storage, normal organismal aging and age-related disease.
Article: " Global view of transcriptome in the brains of aged NR2B transgenic mice," by Chunxia Li1, Men Su1, Huimin Wang1, Yinghe Hu1, 2 (1 Key Lab of Brain Functional Genomics, MOE&STCSM, Institute of Cognitive Neuroscience, East China Normal University, Shanghai 200062, China; 2 Shanghai Engineering Research Center for Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, China)
Li CX, Su M, Wang HM, Hu YH. Global view of transcriptome in the brains of aged NR2B transgenic mice. Neural Regen Res. 2013;8(29):2734-2743.