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Mass spectrometer detection of 10 protein spots after acute high-altitude HBI

Neural Regeneration Research


IMAGE: Following exposure to hypobaric hypoxia for six hours, a large number of neurons exhibited cell shrinkage, karyopyknosis as well as karyolysis (toluidine blue staining, × 400). view more

Credit: Neural Regeneration Research

Hypobaric hypoxia can cause severe brain damage and mitochondrial dysfunction, and is involved in hypoxic brain injury. Dr. Jianyu Li and colleagues from Logistics College of Chinese People's Armed Police Forces evaluated the degree of brain damage with different exposure times to hypoxia and further investigate the differential expression of cerebral mitochondrial proteins by comparative proteomic analysis, in a broader attempt to search for treatment targets of hypobaric hypoxia brain injury. Furthermore, ten protein spots were selected and identified by mass spectrometry. These ten proteins are all involved in the electron transport chain and the function of ATP synthase. These findings were published in the Neural Regeneration Research (Vol. 8, No. 31, 2013).


Article: " Acute high-altitude hypoxic brain injury: Identification of ten differential proteins," by Jianyu Li1, Yuting Qi1, Hui Liu2, Ying Cui1, 3, Li Zhang3, Haiying Gong1, Yaxiao Li1, Lingzhi Li1, 3, Yongliang Zhang3 (1 Department of Pharmaceutical Chemistry, Logistics College of Chinese People's Armed Police Forces, Tianjin 300162, China; 2 Department of Hepatobiliary, Tianjin Third Central Hospital, Tianjin 300170, China; 3 Tianjin Key Laboratory of Occupational and Environmental Hazards Biomarkers, Tianjin 300162, China)

Li JY, Qi YT, Liu H, Cui Y, Zhang L, Gong HY, Li YX, Li LZ, Zhang YL. Acute high-altitude hypoxic brain injury: identification of ten differential proteins. Neural Regen Res. 2013;8(31):2932-2941.


Meng Zhao
Neural Regeneration Research

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