Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. According a study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013), endoplasmic reticulum stress played an important role in the hyperglycemia-induced death of ganglion cells and impairment of retinal microvessels. Tauroursodeoxycholic acid treatment effectively inhibited the activation of the endoplasmic reticulum stress pathway, and provided effective protection against diabetic retinopathy. The C/ERB homologous protein was shown to co-localize with glial fibrillary acidic protein-positive glial cells in the retina of diabetic rats, and subsequently provided evidence for the activation of glial cells in diabetic retinopathy.
Article: " Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy," by Liping Yang1, Lemeng Wu1, Dongmei Wang1, Ying Li1, Hongliang Dou1, Mark O.M.Tso1, 2, Zhizhong Ma1 (1 Department of Ophthalmology, Peking University Third Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100191, China; 2 Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA)
Yang LP, Wu LM, Wang DM, Li Y, Dou HL,Tso MO, Ma ZZ. Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy. Neural Regen Res. 2013;8(33):3148-3158.