The 2014 Dose-Response, Preconditioning: Adaptive Responses in Biology and Medicine will be held at the University of Massachusetts April 22-23, 2014. The conference will explore the rapidly emerging area of preconditioning, its biomedical implications, its dose response features and its underlying mechanisms. Speakers at the conference will address recent discoveries concerning how preconditioning may be used to protect against environmental stressor agents, slow down and prevent a wide range of neurological and cardiovascular diseases, and how such knowledge can be translated into medical practice, taking into consideration the challenges of human inter-individual variation. The convergence of scientists from multiple disciplines on this topic is designed to provide a greater interactive focus on the topic of low dose responses and hopefully prevent further professional/academic isolation with respect to language, concept and interpretation of low dose effects. The conference will also provide the most current advances in the nature of the dose response with respect to chemical and radiation induced stresses as well as a host of effects of pharmaceutical agents that have profound biomedical and risk assessment implications. The conference is approved for CPH Recertification by the National Board of Public Health Examiners.