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JCI early table of contents for Feb. 3, 2014

JCI Journals

Methylation signature correlates with acute myeloid leukemia survival

Acute myeloid leukemia (AML) is characterized by the inappropriate replacement of normal bone marrow with white blood cells due to dysfunctional hematopoietic stem cell (HSC) differentiation. Many of the identified AML-associated mutations lie within genes encoding epigenetic modifiers, suggesting that evaluation of epigenetic signatures could be used to identify sub-groups of AML. In this issue of the Journal of Clinical Investigation, Ulrich Steidl and colleagues at the Albert Einstein College of Medicine compared methylation profiles between healthy populations of HSCs, myeloid progenitor cells, and red blood cell progenitors to evaluate differences in epigenetic profiles and found that the greatest change in epigenetic signatures occurred when HSCs committed to a differentiation pathway. The authors developed a metric of methylation patterns associated with HSC cell fate and evaluated methylation patterns in AML patient samples. The methylation profile in patient samples was prognostic for overall survival, regardless of treatment regime or particular mutation.

TITLE: HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia

Albert Einstein College Of Medicine, Bronx, NY, USA
Phone: (718) 430-3437; E-mail:

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Researchers characterize a biomarker for lysosomal storage disorders

Lysosomal storage disorders (LSDs) are a common cause of neurodegenerative disease in young children. These diseases are difficult to diagnosis in the early stages; therefore, it is difficult to develop therapeutic strategies that prevent symptom onset. In this issue of the Journal of Clinical Investigation, Frances M. Platt and colleagues at the University of Oxford devised a method for evaluating the relative volume of acidic compartments as an indicator of LSDs. Using the commercially available pH-indicator dye, Lysotracker, the authors were able to calculate the relative acidic compartment volume in circulating B cells. Use of this metric in samples from young LSD patients revealed that the relative acidic compartment volume correlated with clinical severity, and could be used to evaluate patient response to a particular therapy.

TITLE: Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker

University of Oxford, Oxford, , GBR
Phone: 01865-271858; E-mail:

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TITLE: Angiotensin converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline

AUTHOR CONTACT: Maya Koronyo-Hamaoui
Cedars-Sinai Medical Center, Los Angeles, CA, USA
Phone: 310-423-4607; Fax: 310-423-0302; E-mail:

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TITLE: Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis

AUTHOR CONTACT: Johanna Ivaska
University Of Turku, Turku, , FIN
Phone: +3587203971;

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TITLE: Hyaluronan digestion controls DC migration from the skin

University of California, San Diego School of Medicine, La Jolla, CA, USA
Phone: 8588224608; Fax: 8588226985; E-mail:

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TITLE: Chemical chaperone ameliorates pathological protein aggregation in plectin-deficient muscle

University of Vienna, Vienna, UNK, AUT
Phone: +43 1 4277 52852; Fax: +43 1 42779748; E-mail:

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TITLE: TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction

AUTHOR CONTACT: Ronald J.E. Pennings
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Phone: +31.24.3617203; Fax: +31.24.3540251; E-mail:

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TITLE: Long-lived intestinal tuft cells serve as colon cancer-initiating cells

Columbia University College of Physicians and Surgeons, New York, NY, USA
Phone: 212-851-4581; Fax: 212-851-4590; E-mail:

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