Identification of factors that influence breast cancer metastasis to bone
One of the more serious and frequent complications of advanced breast cancer is bone metastasis, which is exacerbated by TGF-β signaling; however, it is not clear how TGF-β production is regulated prior to and during metastasis. In this issue of the Journal of Clinical Investigation, Guohong Hu and colleagues at the Shanghai Institutes for Biological Sciences evaluated murine models of invasive breast cancer and determined that cancer cells lacking the putative tumor suppressor DLC1 have a greater propensity toward infiltrating bone, while overexpression of DLC1 inhibited bone colonization. DLC1 knockdown increased TGF-β signaling, resulting in elevated levels of parathyroid hormone-like hormone (PTHLH) and increased metastasis, and pharmacological inhibition of PTHLH production prevented spread to bone. Furthermore, evaluation of clinical breast tumor samples revealed a correlation between reduced DLC1, elevated PTHLH, and bone metastasis.
TITLE: DLC1-dependent parathyroid hormone–like hormone inhibition suppresses breast cancer bone metastasis
AUTHOR CONTACT:
Guohong Hu
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, , CHN
Phone: 86-21-63844516; E-mail: ghhu@sibs.ac.cn
View this article at: http://www.jci.org/articles/view/71812
CELL BIOLOGY
TITLE: Assembly of the cochlear gap junction macromolecular complex requires connexin 26
AUTHOR CONTACT:
Kazusaku Kamiya
Juntendo University Faculty of Medicine, Tokyo, JPN
Phone: +81-3-5802-1229; Fax; E-mail: kkamiya@juntendo.ac.jp
View this article at: http://www.jci.org/articles/view/67621
TITLE: Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis
AUTHOR CONTACT:
Paul Trainor
Stowers Institute for Medical Research, Kansas City, MO, USA
Phone: 816-926-4414; E-mail: pat@stowers.org
View this article at: http://www.jci.org/articles/view/72688
ONCOLOGY
TITLE: SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome
AUTHOR CONTACT:
Guido Marcucci
The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
Phone: 614-366-2261; E-mail: guido.marcucci@osumc.edu
View this article at: http://www.jci.org/articles/view/70921
TITLE: SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas
AUTHOR CONTACT:
Adam Bass
Dana Farber Cancer Institute, Boston, MA, USA
Phone: 6176322477; E-mail: Adam_Bass@dfci.harvard.edu
View this article at: http://www.jci.org/articles/view/71545
NEPHROLOGY
TITLE: Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis
AUTHOR CONTACT:
Erwin Bottinger
Icahn School of Medicine at Mount Sinai, New York, NY, USA
Phone: 212.241.0800; Fax: 212.849.2643 ; E-mail: erwin.bottinger@mssm.edu
View this article at: http://www.jci.org/articles/view/71195
NEUROSCIENCE
TITLE: Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy
AUTHOR CONTACT:
Thomas Gillingwater
University of Edinburgh, Edinburgh, UNK, GBR
Phone: +44 131 6503724; E-mail: T.Gillingwater@ed.ac.uk
View this article at: http://www.jci.org/articles/view/71318
PULMONOLOGY
TITLE: Fibrotic extracellular matrix activates a pro-fibrotic positive feedback loop
AUTHOR CONTACT:
Matthew Parker
University of Minnesota, Minneapolis, USA
Phone: 612-205-2514; E-mail: park0523@umn.edu
View this article at: http://www.jci.org/articles/view/71386
Journal
Journal of Clinical Investigation