Researchers at Central Taiwan University of Science and Technology, Taiwan, led by Prof. Liu, Dr. Shen and Mrs. Yang have developed a biodegradable nerve conduit containing genipin-cross-linked gelatin was annexed using beta-tricalcium phosphate (TCP) ceramic particles (Genipin-Gelatin-TCP, GGT) to bridge the transection of a 15 mm sciatic nerve in rats. The effects of LLL therapy on peripheral nerve restoration and regeneration have systematically investigated throughout the study period.
Very few studies have employed tubulation in combination with diode laser therapy to repair nerve lesions. Furthermore, very few researchers have investigated the influence of LLL therapy on neural regeneration in a biodegradable nerve conduit.
The study, reported on Neural Regeneration Research (Vol. 9, No.12, 2014), confirmed that combining the GGT nerve conduit with an LLL therapy system may be beneficial for the regeneration of nerves across long gaps, as well as for accelerating the reinnervation rate of nerves and improving recruitment in muscles. These benefits may in turn lead to improve functional and morphologic recovery of peripheral nerves. Further studies on the use of LLL therapy as a noninvasive treatment modality for various nerve diseases and injuries could pave the way for mainstream acceptance and standardization of this innovative therapy.
Article: "Roles of reinforced nerve conduits and low-level laser phototherapy for long gap peripheral nerve repair" by Bai-Shuan Liu1, Tsung-Bin Huang2, Shiuh-Chuan Chan3 (1 Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan, China; 2 Department of Bioscience Technology, Chang Jung Christian University, Tainan, Taiwan, China; 3 Graduate Institute of Pharmaceutical Science and Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan, China)
Liu BS, Huang TB, Chan SC. The roles of reinforced nerve conduits and low-level laser phototherapy for peripheral nerve repair. Neural Regen Res. 2014;9(12): 1180-1182.