Neuropeptide Y exhibits neuroprotective effects. Whether the neuroprotective effects are mediated by the pathways including regulating the immunological activity of reactive microglia and reducing cytokines remains unclear. Prof. Wenqing Zhao, Graduate School, Heibei Medical University, China and his team confirmed that neuropeptide Y prevented excessive production of interleukin-1β and tumor necrosis factor-α by inhibiting microglial reactivity, reduced N-methyl-D-aspartate current in rat cortical neurons, preventing excitotoxicity, and thereby protecting neurons. Related results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).
Article: " Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function," by Qijun Li1, Changzheng Dong2, Wenling Li2, Wei Bu3, Jiang Wu2, Wenqing Zhao1, 2 (1 Graduate School, Hebei Medical University, Shijiazhuang, Hebei Province, China; 2 Department of Functional Neurosurgery, Hebei General Hospital, Shijiazhuang, Hebei Province, China; 3 Department of Neurosurgery, Third Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China)
Li QJ, Dong CZ, Li WL, Bu W, Wu J, Zhao WQ. Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function. Neural Regen Res. 2014;9(9):959-967.