Previous studies have shown that Yizhijiannao granule can enhance cognitive performance in Alzheimer's disease patients and Alzheimer's disease-model mice. Further studies revealed that Yizhijiannao granule may exert its therapeutic effect by inhibiting neural cell apoptosis, reducing tau phos-phorylation and relieving neuroinflammation. Dr. Hong Zhu and colleagues who come from Third Xiangya Hospital of Central South University, China treated senescence-accelerated mouse prone 8 mice with Yizhijiannao granule, aiming to identify target-proteins of Yizhijiannao granule that were particularly related to the treatment of Alzheimer's disease. Thirty-seven differential protein spots were found in the temporal lobe area, and finally 10 protein spots were identified. These proteins are separately involved in the regulation of amyloid beta production, oxidative stress, neuroinflammation, regulation of tau phosphorylation, and regulation of neuronal apoptosis. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 13, 2014).
Article: " Treating Alzheimer's disease with Yizhijiannao granules by regulating expression of multiple proteins in temporal lobe," by Hong Zhu1, Liuyang Luo2, Sihang Hu1, Keli Dong1, Guangcheng Li1, Ting Zhang1 (1Department of Traditional Chinese Medicine, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China; 2 Department of Emergency, Bao-an District Hospital of Traditional Chinese Medicine, Shenzhen, Guangdong Province, China)
Zhu H, Luo LY, Hu SH, Dong KL, Li GC, Zhang T. Treating Alzheimer's disease with Yizhijiannao granules by inhibiting neuronal apoptosis. Neural Regen Res. 2014;9(13):1283-1287.