Molecular mechanisms of the Krüppel-like family of transcription factors (KLFs) have been studied more in proliferating cells than in post-mitotic cells such as neurons. Prof. Jeffrey L. Goldberg who comes from University of California San Diego, USA and his team recently found that KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hippocampal and cortical neurons. With at least 15 of 17 KLF family members expressed in neurons and at least 5 structurally unique subfamilies, it is important to determine how this complex family functions in neurons to regulate the intricate genetic programs of axon growth and regeneration. By characterizing the molecular mechanisms of the KLF family in the nervous system, including binding partners and gene targets, and comparing them to defined mechanisms defined outside the nervous system, we may better understand how KLFs regulate neurite growth and axon regeneration. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 15, 2014).
"Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors" by Akintomide Apara1, Jeffrey L. Goldberg2 (1 University of Miami Miller School of Medicine, Miami, FL, USA; 2 Shiley Eye Center, University of California San Diego, La Jolla, CA, USA)
Apara A, Goldberg JL. Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors. Neural Regen Res. 2014;9(15):1418-1421.