Public Release: 

LSU Health tumor registry data find Acadiana colon cancer rates among nation's highest

Louisiana State University Health Sciences Center

New Orleans, LA - A special study using data from LSU Health New Orleans School of Public Health's Louisiana Tumor Registry has found that colorectal cancer incidence rates in the Louisiana Acadian parishes are among the highest in the United States. This study appears to be the first to identify a high rate of cancer in a large, regional, US founder population, raising the possibility of a genetic predisposition. Alternatively, an unidentified, robust environmental risk factor may be present. The paper is published online in Clinical and Translational Gastroenterology, a Nature journal, at http://www.nature.com/ctg/journal/v5/n10/full/ctg201410a.html.

The study was led by Dr. Jordan Karlitz, Division of Gastroenterology at Tulane University School of Medicine who is also adjunct faculty at the LSU Health New Orleans School of Public Health, Dr. Xiao-Cheng Wu, Professor of Public Health and Director of the LSU Health New Orleans Louisiana Tumor Registry, Dr. Vivien Chen, LSU Health Professor of Public Health, and Dr. Elizabeth Fontham, Professor and Founding Dean Emeritus of the LSU Health New Orleans School of Public Health.

The research team chose to study the Acadian parishes where French is spoken as these parishes are home to the Cajun population that migrated to the region in the 1700s from Canada and France. The Cajuns are a founder population - a new population founded by a small number of individuals who have limited genetic variation relative to the larger original population. Founder populations are important to study as diseases with a hereditary basis, such as certain genetic conditions and cancers, can be seen with increased frequency. Results can yield important information about cancer susceptibility genes not only for the population being studied, but for others worldwide who may share a similar heritage.

The research team identified 18 Acadian parishes and stratified 2005-2009 cancer incidence data by age, ethnicity and gender by utilizing French language census data. A total of 3,288 colorectal cancer cases were identified in the Acadian region and 11,737 in Louisiana. They identified a subgroup of 9 parishes with higher proportions of French speakers, a marker for the Cajun population. Colorectal cancer rates in whites and white males in the 18 parishes were statistically significantly higher than both Louisiana and US rates. In the 9 parishes, rates increased further; whites had an incidence of 56.1 per 100,000, 13% higher than Louisiana and 23% higher than the US rate. In white males, incidence was 72.6 per 100,000, 19% higher than Louisiana and 37% higher than the US rate. If the 9-parish region were considered a "state," white males would have the highest colorectal cancer incidence in the United States by 11% compared with other white male populations.

"This study has identified disproportionately high rates of colorectal cancer in the Acadian parishes of Louisiana," says Dr. Karlitz. "The research highlights the importance of utilizing data made available by high-quality population-based cancer registries to identify at-risk populations that can have important implications with regard to health care delivery. Future studies to assess genetic and environmental risk factors will be necessary to better understand the colorectal cancer incidence in this population."

"This study demonstrates the importance of the Louisiana Tumor Registry at the LSU Health New Orleans School of Public Health in identifying areas and populations at high risk of cancer. Without the population-based state registry, we would not have such data for cancer control and research," notes Dr. Wu.

Concludes senior author Dr. Elizabeth Fontham, who is from the region, "This study has provided provocative findings of a potential link between high colorectal cancer risk and the Acadian population of south Louisiana. Additional studies in this population are important in order to better understand the roles of specific factors, both genetic and/or environmental."

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The research team also included registry liaison Patricia Andrews, MPH, Instructor of Epidemiology at LSU Health New Orleans School of Public Health, and Dr. Christine Blanton, Division of Gastroenterology at the Tulane University School of Medicine.

This study was supported by National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) grant # HHSN2612013000161 to LSU Health New Orleans and Centers for Disease Control and Prevention National Program of Cancer Registries grant # 5U58DP003915 to LSU Health New Orleans.

The National Cancer Institute designated LSU Health New Orleans' Louisiana Tumor Registry as a SEER registry in 2001. It is one of 18 registries in the United States comprising the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. The SEER Program is the only comprehensive source of population-based information in the United States that includes stage of cancer at the time of diagnosis and patient survival data. The SEER Program is considered the standard for quality among cancer registries around the world.

LSU Health Sciences Center New Orleans educates Louisiana's health care professionals. The state's health university leader, LSU Health New Orleans includes a School of Medicine, the state's only School of Dentistry, Louisiana's only public School of Public Health, and Schools of Allied Health Professions, Nursing, and Graduate Studies. LSU Health New Orleans faculty take care of patients in public and private hospitals and clinics throughout the region. In the vanguard of biosciences research in a number of areas in a worldwide arena, the LSU Health New Orleans research enterprise generates jobs and enormous economic impact. LSU Health New Orleans faculty have made lifesaving discoveries and continue to work to prevent, advance treatment, or cure disease. To learn more, visit http://www.lsuhsc.edu, http://www.twitter.com/LSUHSCHealth or http://www.facebook.com/LSUHSC.

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