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Current models for predicting outcomes after mild traumatic brain injury perform poorly

Mary Ann Liebert, Inc./Genetic Engineering News

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Credit: ©Mary Ann Liebert, Inc., publishers

New Rochelle, NY, October 14, 2014--For the 5-15% of patients with mild traumatic brain injury (mTBI) who will have lingering physical, behavioral, or cognitive problems 3 to 6 months after their injury, identification of this at-risk population is essential for early intervention. Existing models used to predict poor outcomes after mTBI are unsatisfactory, according to a new study, and new, more relevant predictive factors are different than those used in cases of moderate or severe TBI, as described in the study published in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Neurotrauma website at http://online.liebertpub.com/doi/pdfplus/10.1089/neu.2014.3384 until November 14, 2014.

Hester F. Lingsma and a multidisciplinary, international team of authors evaluated two existing prognostic models for mTBI in patients selected from the TRACK-TBI Pilot observational study carried out at three medical centers in the U.S. Both models performed poorly. Based on further analysis, the authors identified older age, pre-existing psychiatric conditions, and less education as the three strongest predictors of poor outcomes, as they report in the article "Outcome Prediction after Mild and Complicated Mild Traumatic Brain Injury: External Validation of Existing Models and Identification of New Predictors Using the TRACK-TBI Pilot Study."

John T. Povlishock, PhD, Editor-in-Chief of Journal of Neurotrauma and Professor, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, notes that, "this is an extremely important study utilizing the TRACK-TBI database. This meticulously performed investigation highlights the dangers in assessing outcome following mTBI, emphasizing that other comorbid factors such as older age, preexisting psychiatric disorders, and less education, perhaps a function of socioeconomic status, can negatively impact outcome. This important communication should be considered routinely as we move forward in our assessments of outcomes following mTBI, whether or not these outcomes are framed in the context of advanced imaging, biomarker evaluation, and/or other metabolic/functional screens."

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About the Journal

Journal of Neurotrauma is an authoritative peer-reviewed journal published 24 times per year in print and online that focuses on the latest advances in the clinical and laboratory investigation of traumatic brain and spinal cord injury. Emphasis is on the basic pathobiology of injury to the nervous system, and the papers and reviews evaluate preclinical and clinical trials targeted at improving the early management and long-term care and recovery of patients with traumatic brain injury. Journal of Neurotrauma is the official journal of the National Neurotrauma Society and the International Neurotrauma Society. Complete tables of content and a sample issue may be viewed on the Journal of Neurotrauma website at http://www.liebertpub.com/neu.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in promising areas of science and biomedical research, including Therapeutic Hypothermia and Temperature Management, Brain Connectivity, and Tissue Engineering. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website at http://www.liebertpub.com.

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