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Quality of biopsy directly linked to survival in bladder cancer patients

About half of patients don't get a sufficient biopsy sample to properly stage their cancer

University of California - Los Angeles Health Sciences

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IMAGE: This is Dr. Karim Chamie. view more

Credit: UCLA

UCLA researchers have shown for the first time that the quality of diagnostic staging using biopsy in patients with bladder cancer is directly linked with survival, meaning those that don't get optimal biopsies are more likely to die from their disease.

The two-year study found that about half of bladder cancer patients who were biopsied had insufficient material - meaning there was no bladder wall muscle retrieved - to accurately stage the cancer. Additionally, the UCLA research team found that a suboptimal biopsy and incorrect tumor staging was associated with a significant increase in deaths from bladder cancer, said study first author Dr. Karim Chamie, an assistant professor of urology and surgical director of the bladder cancer program at UCLA.

"These findings are very important because while patients know about the stage of their cancer, they rarely question the quality of the biopsy," said Chamie, who also is a researcher at UCLA's Jonsson Comprehensive Cancer Center. "We hope these findings will help empower patients to ask about the quality of their biopsy and, if it is suboptimal, then urge their doctors to repeat the biopsy prior to deciding on what type of treatment to prescribe."

The findings were published Oct. 20, 2014 in the early, online edition of the peer-reviewed journal Cancer. The study was conducted at UCLA and the Cancer Surveillance Program at USC.

Chamie said that many times, biopsies only take tissue from the inner lining of the bladder itself, ignoring the underlying muscle wall. If the cancer has started to invade, tissue from the muscle wall needs to be examined to determine the next course of treatment.

For the study, the UCLA team reviewed the medical records of every patient diagnosed with "non-invasive" - meaning the cancer had yet not spread into the muscle - bladder cancer during the years 2004 and 2005 across medical institutes in Los Angeles County. Biopsy and surgery reports were reviewed.

The team found that about half the time, the surgeon either did not do an adequate biopsy or the pathologist did not clearly state the extent of the cancer invasion. When patients had aggressive tumors and their surgeons and pathologists appropriately staged them, the chance of dying of bladder cancer at five years was 8 percent.

If the surgeon did an inadequate job staging them, but the pathologist alerted the physician of inadequate staging, the five-year mortality rate was 12 percent.

However, if the pathologist did not comment on the extent of the cancer invasion, then the five-year mortality was 19 percent.

"Appropriately staging patients with bladder cancer is a skill set that every urologist and pathologist should have in his/her armamentarium," Chamie said. "We believe the next step is to change the staging system for bladder cancer to incorporate the quality of staging. Not all stage I cancers are alike. Some patients may have stage II cancer, but because the biopsy was insufficient, these patients were inaccurately staged and may be undertreated. I really do believe that one reason why we have yet to see significant improvement in bladder cancer survival over the last two decades may, in part, be attributed to inadequate staging."

The study sample included 1,865 patients, 335 urologists and 278 pathologists from medical institutes across Los Angeles County. Muscle was reported as present in 972, or 52.1 percent, absent in 564, or 30.2 percent, and was not mentioned at all in 329, or 17.7 percent of initial pathology reports.

Barbara James, 77, of Three Rivers in Central California was diagnosed bladder cancer a year ago by an urologist in her area, who also performed a biopsy and later removed the cancer. However, the urologist waited four months before going back in to check to ensure all the cancer was removed, James said.

More cancer was found and the urologist wanted to go in and remove more.

"It made me really nervous. I felt like he didn't know what he was doing," she said. "I decided I needed to go somewhere else."

A friend, a neurosurgeon at UCLA, referred James to Chamie, who performed a more thorough biopsy, which found that James had invasive bladder cancer that was missed in the first biopsy. As a result, her bladder had to be removed and a new bladder built for her using a portion of her intestine. She's recovering and advises anyone with bladder cancer to go to a major medical center for biopsy and staging.

Every year, nearly 75,000 Americans are diagnosed with bladder cancer, the vast majority with non-invasive disease. More than 15,500 will die.

"The omission of muscle in the specimen or its mention in the pathology report in nearly half of all diagnostic resections is associated with increased mortality, particularly in patients with aggressive disease," the study states. "Because urologists cannot reliably discern between aggressive and indolent disease, we recommend that patients with bladder cancer should undergo adequate muscle sampling at the time of biopsy."

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The study was funded by the National Cancer Institute, UCLA's Jonsson Comprehensive Cancer Center, the Surveillance, Epidemiology, and End Results Program and the STOP Cancer Foundation.

For more than 50 years, the urology specialists at UCLA have continued to break new ground and set the standards of care for patients suffering from urological conditions. In collaboration with research scientists, UCLA's internationally renowned physicians are pioneering new, less invasive methods of delivering care that are more effective and less costly. UCLA's is one of only a handful of urology programs in the country that offer kidney and pancreas transplantation. In July of 2014, UCLA Urology was once again ranked fourth in the nation by U.S. News & World Report, a ranking it has held for the last 15 years. For more information, visit http://urology.ucla.edu/.

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