Public Release: 

Vital exhaustion may raise risk of first-time cardiovascular disease

Abstract 17412 (Hall A2, Core 2)

American Heart Association

Fatigue, increased irritability and feeling demoralized -- a combination known as vital exhaustion -- may raise the risk of first-time cardiovascular disease in otherwise healthy men and women, according to research presented at the American Heart Association's Scientific Sessions 2014.

Researchers examined the relationship between vital exhaustion and first-time heart disease in 11 prospective studies that involved more than 60,000 people without heart disease. The studies had an average six and half years of follow-up.

After adjusting for other factors, researchers observed a 36 percent increased risk of developing first-time cardiovascular disease from vital exhaustion.

"Vital exhaustion is a significant risk factor for incident cardiovascular disease in healthy subjects, comparable to some of the other psychological risk factors for cardiac disease," researchers said.


Randy Cohen, M.D., cardiologist, Mt. Sinai St. Luke's-Roosevelt Hospital Center, New York, New York

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