November 3, 2014 - A new study shows cellular-level changes in nerve structure and function that may contribute to the development of migraine headaches, reports the November issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Nerve specimens from patients with migraine show abnormalities of the myelin sheath that serves as "insulation" around the nerve fibers," according to the study by ASPS Member Surgeon Bahman Guyuron, MD, of Case Western Reserve University, Cleveland. The findings help to explain why a plastic surgery procedure provides effective pain relief for migraine patients--and may provide useful clues for developing new approaches to migraine treatment.
Nerve Fiber Abnormalities in Patients with Migraine...
The researchers performed in-depth studies on tiny specimens of the trigeminal nerve (one of the cranial nerves), from 15 patients who underwent surgical treatment for migraine. Sample from 15 patients undergoing a cosmetic forehead lift procedure were studied for comparison. The study--conducted through collaboration by three independent departments at Case Western Reserve School of Medicine--included electron microscopy to assess nerve cell structure and proteomic analysis to assess the presence and function of proteins.
The results showed important differences in nerve structure between the migraine and cosmetic surgery patients. "Essentially, the protective layer surrounding and insulating the normal nerves, called myelin, is missing or is defective on the nerves of the patients with migraine headaches," said Dr. Guyuron.
He likens the myelin sheath to the plastic coating used as insulation material around electrical wires and cables. "If the insulation becomes cracked or damaged by conditions in the environment, that's going to affect the cable's ability to perform its normal function," said Dr Guyuron. "In a similar way, damage to the myelin sheath may make the nerves more prone to irritation by the dynamic structure surrounding them, such as muscle and blood vessels, potentially triggering migraine attacks."
Organization of the cellular elements in nerve fibers also differed between groups. Healthy nerves were tightly organized with elements uniformly distributed through the nerve, while nerves from migraine patients showed discontinuous, "patchy" distribution.
...Suggest Reasons Why Migraine Surgery May Be Effective
Dr Guyuron developed migraine surgery techniques after noticing that some migraine patients had reduced headache activity after cosmetic forehead-lifting, which involved removal of some muscle and vessel tissue surrounding the cranial nerves. The new study lends some important new clues for understanding the mechanisms by which migraine headaches occur. It also adds new evidence that the peripheral nerves play an important role in triggering the complex cascade of migraine attacks that ultimately involve the central nervous system.
By showing pathological changes of a cranial nerve involved in triggering migraine headaches, the study may help to explain why migraine surgery is effective. Dr Guyuron and coauthors write, "These findings may also lead to other opportunities to treat patients with migraine headaches non-invasively, or with less invasive procedures that repair the defective myelin around nerves, lending additional protection for the nerves."
The new findings on nerve cell abnormalities associated with migraine are discussed in this month's introductory video by Rod J. Rohrich, MD, Editor-in-Chief, on the Plastic and Reconstructive Surgery website. "This type of cutting edge research...is just one way plastic surgeons are constantly trying to improve patients' outcomes," Dr Rohrich concludes.
About Plastic and Reconstructive Surgery
For more than 60 years, Plastic and Reconstructive Surgery® has been the one consistently excellent reference for every specialist who uses plastic surgery techniques or works in conjunction with a plastic surgeon. The official journal of the American Society of Plastic Surgeons, Plastic and Reconstructive Surgery® brings subscribers up-to-the-minute reports on the latest techniques and follow-up for all areas of plastic and reconstructive surgery, including breast reconstruction, experimental studies, maxillofacial reconstruction, hand and microsurgery, burn repair, and cosmetic surgery, as well as news on medico-legal issues.
The American Society of Plastic Surgeons (ASPS) is the world's largest organization of board-certified plastic surgeons. Representing more than 7,000 Member Surgeons, the Society is recognized as a leading authority and information source on aesthetic and reconstructive plastic surgery. ASPS comprises more than 94 percent of all board-certified plastic surgeons in the United States. Founded in 1931, the Society represents physicians certified by The American Board of Plastic Surgery or The Royal College of Physicians and Surgeons of Canada. ASPS advances quality care to plastic surgery patients by encouraging high standards of training, ethics, physician practice and research in plastic surgery. You can learn more and visit the American Society of Plastic Surgeons at http://www.
About Wolters Kluwer Health
Wolters Kluwer Health is a leading global provider of information, business intelligence and point-of-care solutions for the healthcare industry. Serving more than 150 countries worldwide, clinicians rely on Wolters Kluwer Health's market leading information-enabled tools and software solutions throughout their professional careers from training to research to practice. Major brands include Health Language®, Lexicomp®, Lippincott Williams & Wilkins, Medicom®, Medknow, Ovid®, Pharmacy OneSource®, ProVation® Medical and UpToDate®.
Wolters Kluwer Health is part of Wolters Kluwer, a market-leading global information services company. Wolters Kluwer had 2013 annual revenues of €3.6 billion ($4.7 billion), employs approximately 19,000 people worldwide, and maintains operations in over 40 countries across Europe, North America, Asia Pacific, and Latin America.maintains operations in over 40 countries across Europe, North America, Asia Pacific, and Latin America. Wolters Kluwer is headquartered in Alphen aan den Rijn, the Netherlands. Its shares are quoted on Euronext Amsterdam (WKL) and are included in the AEX and Euronext 100 indices. Wolters Kluwer has a sponsored Level 1 American Depositary Receipt program. The ADRs are traded on the over-the-counter market in the U.S. (WTKWY).
Follow our official Twitter handle: @WKHealth.