Public Release: 

Northwestern Medicine surgeons first to treat brain tumor using adaptive hybrid technology

Northwestern Memorial HealthCare

CHICAGO - It started with numbness on the left side of his face. A few months later, Steve Mores couldn't feel his tongue or chew on the left side of his mouth. TV commercials featuring food or even being in a grocery store made him nauseous. A long time drummer in a popular band, Mores lost 30 pounds and had to find a replacement.

He eventually discovered his issues were caused by a benign, slow growing brain tumor called a vestibular schwannoma. He tried several rounds of radiation to shrink the tumor, but that only made his symptoms worse.

That's when the Aurora resident turned to Northwestern Medicine neurosurgeon Orin Bloch, MD, who determined that because the tumor was growing, surgery was Mores' best option. However because of the tumor's precarious location, the operation to remove the tumor could potentially cause hearing loss or even partial facial paralysis.

However, Northwestern Medicine neurosurgeons are spearheading new adaptive hybrid surgery technology to help patients like Mores. Participating in a phase 1 research study, Mores was one of the first subjects in the United States to have a brain tumor removed using this technology that integrates a radiosurgery plan into surgery. Planning for follow-up radiosurgery during a brain surgery - or in Mores' case using his radiation data during surgery - is intended to help doctors more safely remove the right amount of tumor while more accurately balancing the risks of surgery with the risks of radiosurgery toxicity.

"The goal of every brain tumor surgery is to remove as much of the tumor as possible without harming parts of the brain that control vital things such as speech, hearing or movement," said Andrew Parsa, MD, PhD, the chair of neurological surgery at Northwestern Memorial Hospital and the Michael J. Marchese Professor and chair of the department of neurological surgery at Northwestern University Feinberg School of Medicine. "Studying the results of this type of adaptive hybrid treatment could change the way we treat benign and cancerous growths. Instead of using an MRI after a surgery to find out how much of a tumor is left behind, we may be able to get answers and make adjustments in real time during surgery using adaptive hybrid technology."

Parsa and Bloch performed Mores' surgery on Oct. 16, 2014. To date, the outcome has been positive with no detectable damage to Mores' hearing or facial nerve. He was discharged from the hospital less than a week after his surgery.

Vestibular schwannomas, which are also known as acoustic neuromas, are benign and usually slow growing tumors that develop from the nerves supplying the inner ear. As these tumors grow, they press against the balance and hearing nerves, which can cause loss of hearing, ringing in the ear or loss of balance. If the tumor presses against the facial nerve, facial weakness and even paralysis can occur. Pressure on the nerve controlling sensation to the face and head, called the trigeminal nerve, can cause patients like Mores to experience debilitating pain or numbness, Eventually, vestibular schwannomas may grow so large that they press on the brain stem or cerebellum and become life threatening.

"Ideally, adaptive hybrid surgery is meant to be used by performing surgery first, followed by radiation," said Bloch. "However, we can also fix less than ideal radiation treatments by doing adaptive hybrid surgery in reverse, using radiation treatment data and overlaying it on the surgical navigation. By using this technique, we were able to remove nearly all of Steve's tumor and resolve many of his symptoms immediately."

In fact, Mores recently climbed back onto his drum stool and reunited with his band, Prairie Surfers, A vice president of sales with a team of account reps, Mores is also looking forward to his first business trip in months.

"As soon as I woke up from surgery I could feel the left side of my face," said Mores, a 57-year-old father of three grown boys. "I'm still recovering but every day, I feel a little better. Surgery wasn't the answer I wanted, but after I met the doctors at Northwestern hospital, I was glad they were the ones doing it."

###

Northwestern Medicine is home to the best neurosurgery program in Illinois and the 10th best program in the nation as ranked by U.S. News & World Report. For more information on Northwestern Medicine's neurosurgery program, visit http://neurosurgery.nm.org/

About Northwestern Medicine®

Northwestern Medicine® is the collaboration between Northwestern Memorial HealthCare and Northwestern University Feinberg School of Medicine around a strategic vision to transform the future of healthcare. It encompasses the research, teaching and patient care activities of the academic medical center. Sharing a commitment to superior quality, academic excellence and patient safety, the organizations within Northwestern Medicine comprise more than 9,000 clinical and administrative staff, 3,100 medical and science faculty and 700 students. The entities involved in Northwestern Medicine remain separate organizations. Northwestern Medicine is a trademark of Northwestern Memorial HealthCare and is used by Northwestern University.

About Northwestern Memorial Hospital

Northwestern Memorial is one of the country's premier academic medical center hospitals and is the primary teaching hospital of the Northwestern University Feinberg School of Medicine. Along with its Prentice Women's Hospital and Stone Institute of Psychiatry, the hospital has 1,705 affiliated physicians and 6,769 employees. Northwestern Memorial is recognized for providing exemplary patient care and state-of-the art advancements in the areas of cardiovascular care; women's health; oncology; neurology and neurosurgery; solid organ and soft tissue transplants and orthopaedics.

Northwestern Memorial has nursing Magnet Status, the nation's highest recognition for patient care and nursing excellence. Northwestern Memorial ranks 10th in the nation in the U.S. News & World Report 2014-15 Honor Roll of America's Best Hospitals. The hospital is recognized in 14 of 16 clinical specialties rated by U.S. News and is No. 1 in Illinois and Chicago in U.S. News' 2014-15 state and metro rankings, respectively. For 15 years running, Northwestern Memorial has been rated among the "100 Best Companies for Working Mothers" guide by Working Mother magazine. The hospital is a recipient of the prestigious National Quality Health Care Award and has been chosen by Chicagoans as the Consumer Choice according to the National Research Corporation's annual survey for 15 consecutive years.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.