February 19, 2015--(BRONX, NY)--Researchers at Albert Einstein College of Medicine of Yeshiva University have found a possible clue to why older mothers face a higher risk for having babies born with conditions such as Down syndrome that are characterized by abnormal chromosome numbers.
Using data from more than 4,000 families obtained in collaboration with the direct-to-consumer genetic testing company 23andMe, Inc., the study showed that the normal process by which parental chromosomes are shuffled before being passed to children appears to be less regulated in older mothers. The study was published online today in Nature Communications.
The research focuses on meiosis, the specialized type of cell division in which cells containing the 46 chromosomes (23 pairs) normally found in human cells separate to form sperm or egg cells that contain 23 chromosomes, one from each of the 23 chromosomal pairs. Before they separate, the pairs of chromosomes exchange genetic material with each other--a chromosomal shuffling process known as recombination. Recombination is vital to a species' genetic diversity, ensuring that sperm or eggs will have novel combinations of genetic traits. However, failures of recombination can introduce errors such as aneuploidy (abnormal chromosome numbers in eggs or sperm) or large chromosomal rearrangements. The findings from this study show for the first time that the spacing between recombination events occurring on the same chromosomes becomes less constrained as women age.
"It's been known for many years that the rate of recombination varies across the genome, but less is known about how the rate of recombination changes with parental age," said study leader Adam Auton, Ph.D., assistant professor of genetics and of epidemiology & population health at Einstein.
The Einstein study involved genetic data gathered from more than 4,200 families (each with at least two children), homing in on recombinations that had passed from parent to offspring. All told, the researchers examined more than 645,000 recombination events.*
The researchers confirmed that the number of recombination events transmitted from mother to child increases with maternal age. In addition, they also discovered that, for older mothers, more recombination events occur in close proximity to each other. By contrast, no such age-related effects were observed in fathers.
"We know there are cellular processes that tightly regulate the process of recombination," said Dr. Auton. "So the greater rate of recombination we observed in the chromosomes of older mothers could imply that this tight regulation becomes weaker with age. Basically, recombination appears to be a more dynamic process than we previously appreciated."
The researchers note that their findings have no clinical application as yet. "Our study adds to the understanding of the basic biology of meiosis and how recombination shapes the evolution of the human species," said Dr. Auton. "In the long run, it may help us understand how aneuploidy or certain types of genetic mutation can occur through failures of recombination."
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*Data was contributed by 23andMe customers who provided informed consent to take part in this research under a protocol approved by the AAHRPP-accredited institutional review board, Ethical and Independent Review Services.
The paper is titled "Escape from crossover interference increases with maternal age." The other authors are: Christopher L. Campbell, a Ph.D. student at Einstein; Nicholas A. Furlotte, Nick Eriksson, and David Hinds, all affiliated with 23andMe.
Nicholas A. Furlotte and David Hinds are current 23andMe employees and Nick Eriksson is a former 23andMe employee; all three have private equity interest in the company. The remaining authors declare no competing financial interests.
This study was supported in part by Albert Einstein College of Medicine, and by grants from the National Institutes of Health to Einstein (T32-GM007491) and 23andMe (2R44HG006981-02).
About Albert Einstein College of Medicine of Yeshiva University
Albert Einstein College of Medicine of Yeshiva University is one of the nation’s premier centers for research, medical education and clinical investigation. During the 2013-2014 academic year, Einstein is home to 743 M.D. students, 275 Ph.D. students, 103 students in the combined M.D./Ph.D. program, and 313 postdoctoral research fellows. The College of Medicine has more than 2,000 full-time faculty members located on the main campus and at its clinical affiliates. In 2013, Einstein received more than $150 million in awards from the National Institutes of Health (NIH). This includes the funding of major research centers at Einstein in aging, intellectual development disorders, diabetes, cancer, clinical and translational research, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Its partnership with Montefiore Medical Center, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. Through its extensive affiliation network involving Montefiore, Jacobi Medical Center –- Einstein’s founding hospital, and three other hospital systems in the Bronx, Brooklyn and on Long Island, Einstein runs one of the largest residency and fellowship training programs in the medical and dental professions in the United States. For more information, please visit www.einstein.yu.edu, read our blog, follow us on Twitter, like us on Facebook, and view us on YouTube.
Journal
Nature Communications