Public Release: 

Excessive vitamin intake in pregnant rats impacts food choices in offspring

Canadian Science Publishing (NRC Research Press)

This news release is available in French.

A research group at the Department of Nutritional Sciences at the University of Toronto, Faculty of Medicine has been using a rat model to see how maternal intake of above-requirement vitamins (A, D, E, and K) impact offspring's brain development and behaviour. Some of their findings were published today in the journal Applied Physiology, Nutrition, and Metabolism.

Much research on vitamins focuses on prevention of deficiencies and the toxicity of very high intakes. However, little has been done on the effect of intakes above requirements as may be common in current diets because of the mandatory fortification of food to prevent deficiencies, discretionary additions of nutrients to foods (such as cereals), and an increased use of health foods and vitamin supplements. During pregnancy many women consume better quality diets, but are also likely to use vitamin supplements, which combined may exceed vitamin intake requirements.

Fat soluble vitamins have distinct roles in fetal growth and development and this study's objective was to determine the effects of a high fat soluble vitamin diet during pregnancy on body weight gain, food intake and preference for palatable solutions in male Wistar rat offspring. This results showed little effect on weight gain and food intake but did find that brain development and food preference were affected.

According to Dr. Harvey Anderson, principal investigator and a co-author of the study, the research showed that high-vitamin maternal diets affected hedonic pathways regulating food preference in the offspring. For example, the preference for sweetness was decreased; meaning the pups drank less of a sugar solution if their mothers were on the high vitamin diets. Thus, it seems consumption of these vitamins above requirements needed for healthy brains may impact offspring's dietary food preferences and potentially other associated behaviours.

"While these data provide novel information on the fundamental role of fat soluble vitamins in brain development, the rat brain developmental stages are not the same as in the human," explains Dr. Anderson, a co-author of this research study. "Nevertheless, it is clear we know little about the effect of vitamins when taken above requirements on brain development."

The application to human mothers and their offspring remains to be determined.

The article "A gestational diet high in fat soluble vitamins alters expression of genes in 1 brain pathways and reduces sucrose preference, but not food intake, in Wistar male rat offspring" by Sanchez-Hernandez et al. was published today in the journal Applied Physiology, Nutrition, and Metabolism.

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Direct link to article: http://www.nrcresearchpress.com/doi/abs/10.1139/apnm-2014-0480

This research was supported by the Canadian Institute of Health Research, Institute of Nutrition, Metabolism and Diabetes (CIHR-INMD), Reference MOP-93624.

Please cite Applied Physiology, Nutrition, and Metabolism as the source of this story and include hyperlink to research study: dx.doi.org/10.1139/apnm-2014-0480

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