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With geomagnetic compass hooked to the brain, blind rats act like they can see

Cell Press

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IMAGE: This is an illustration of a rat wearing the geomagnetic device. view more

Credit: Norimoto and Ikegaya

By attaching a microstimulator and geomagnetic compass to the brains of blind rats, researchers reporting in the Cell Press journal Current Biology on April 2 found that the animals can spontaneously learn to use new information about their location to navigate through a maze nearly as well as normally sighted rats. Researchers say the findings suggest that a similar kind of neuroprosthesis might also help blind people walk freely through the world.

Most notably, perhaps, the findings show the incredible flexibility of the mammalian brain.

"The most remarkable point of this paper is to show the potential, or the latent ability, of the brain," says Yuji Ikegaya of the University of Tokyo. "That is, we demonstrated that the mammalian brain is flexible even in adulthood--enough to adaptively incorporate a novel, never-experienced, non-inherent modality into the pre-existing information sources."

In other words, he says, the brains of the animals they studied were ready and willing to fill in "the 'world' drawn by the five senses" with a new sensory input.

What Ikegaya and his colleague Hiroaki Norimoto set out to do was to restore not vision per se, but the blind rats' allocentric sense. That sense is what allows animals and people to recognize the position of their body within the environment. What would happen, the researchers asked, if the animals could "see" a geomagnetic signal? Could that signal fill in for the animals' lost sight? Would the animals know what to do with the information?

The head-mountable geomagnetic sensor device the researchers devised allowed them to connect a digital compass (the kind you'd find in any smart phone) to two tungsten microelectrodes for stimulating the visual cortex of the brain. The very lightweight device also allowed the researchers to turn the brain stimulation up or down and included a rechargeable battery. Once attached, the sensor automatically detected the animal's head direction and generated electrical stimulation pulses indicating which direction they were facing--north or south, for instance.

The "blind" rats were then trained to seek food pellets in a T-shaped or a more complicated maze. Within tens of trials, the researchers report, the animals learned to use the geomagnetic information to solve the mazes. In fact, their performance levels and navigation strategies were similar to those of normally sighted rats. The animals' allocentric sense was restored.

"We were surprised that rats can comprehend a new sense that had never been experienced or 'explained by anybody' and can learn to use it in behavioral tasks within only two to three days," Ikegaya says.

The findings suggest one very simple application: to attach geomagnetic sensors to the canes used by some blind people to get around. More broadly, the researchers expect, based on the findings, that humans could expand their senses through artificial sensors that detect geomagnetic input, ultraviolet radiation, ultrasound waves, and more. Our brains, it appears, are capable of much more than our limited senses allow.

"Perhaps you do not yet make full use of your brain," Ikegaya says. "The limitation does not come from your lack of effort, but it does come from the poor sensory organs of your body. The real sensory world must be much more 'colorful' than what you are currently experiencing."

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Current Biology, Norimoto et al.: "Visual Cortical Prosthesis with a Geomagnetic Compass Restores Spatial Navigation in Blind Rats"

Current Biology, published by Cell Press, is a bimonthly journal that features papers across all areas of biology. Current Biology strives to foster communication across fields of biology, both by publishing important findings of general interest and through highly accessible front matter for non-specialists. For more information please visit http://www.cell.com/current-biology. To receive media alerts for Current Biology or other Cell Press journals, contact press@cell.com.

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