Public Release: 

Sugar-sweetened beverages suppress the body's stress response

Researchers warn chronic stress could prompt habit-forming sugar overconsumption

The Endocrine Society

Washington, DC--Drinking sugar-sweetened beverages can suppress the hormone cortisol and stress responses in the brain, but diet beverages sweetened with aspartame do not have the same effect, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

"This is the first evidence that high sugar - but not aspartame - consumption may relieve stress in humans," said one of the study's authors, Kevin D. Laugero, PhD, of the University of California, Davis, and the U.S. Department of Agriculture's Agricultural Research Service. "The concern is psychological or emotional stress could trigger the habitual overconsumption of sugar and amplify sugar's detrimental health effects, including obesity."

About 35 percent of adults and nearly 17 percent of children nationwide are obese, according to the Society's Endocrine Facts & Figures report. Sugary drinks such as soda and juice have been linked to this problem. Half of the U.S. population consumes sugar-sweetened drinks on any given day, according to the U.S. Centers for Disease Control and Prevention.

The parallel-arm, double-masked diet intervention study examined the effects of consuming sugar- and aspartame-sweetened beverages on a group of 19 women between the ages of 18 and 40. The researchers assigned eight women to consume aspartame-sweetened beverages, and 11 to drink sugar-sweetened beverages. For a 12-day period, the women drank one of the assigned beverages at breakfast, lunch and dinner. The participants were instructed not to consumer other sugar-sweetened drinks, including fruit juice.

For 3.5 days prior to and after the study, the women consumed a standardized low-sugar diet and stayed at the UC Davis Clinical and Translational Science Center's Clinical Research Center.

Before and after the 12-day experimental period, the women underwent functional MRI screenings after performing math tests to gauge the brain's stress response. The participants also provided saliva samples to measure levels of cortisol - a hormone made by the adrenal glands that is essential for the body's response to stress.

The researchers found women who drank sugar-sweetened beverages during the study had a diminished cortisol response to the math test, compared to women who were assigned to consume aspartame-sweetened beverages. In addition, the women who consumed sugar-sweetened beverages exhibited more activity in the hippocampus - a part of the brain that is involved in memory and is sensitive to stress - than the women who drank aspartame-sweetened beverages.

The hippocampus typically is less active when the body is under stress. When the study participants drank sugar-sweetened beverages, this response was inhibited. The findings offer new clues that help explain how sugar positively reinforces the temptation to eat comfort food when a person is stressed, Laugero said.

"The results suggest differences in dietary habits may explain why some people underreact to stressful situations and others overreact," he said. "Although it may be tempting to suppress feelings of stress, a normal reaction to stress is important to good health. Research has linked over- and under-reactivity in neural and endocrine stress systems to poor mental and physical health."

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Other authors of the study include: Matthew S. Tryon, Kimber L. Stanhope, Valentina Medici and Peter J. Havel of the University of California, Davis in Davis, CA; and Elissa S. Epel, Ashley E. Mason and Rashida Brown of the University of California, San Francisco in San Francisco, CA.

The study, "Excessive Sugar Consumption May Be a Difficult Habit to Break: A View from the Brain and Body," will be published online at http://press.endocrine.org/doi/10.1210/jc.2014-4353, ahead of print.

For more information on the high costs of junk food, visit the Hormone Health Network's website.

Founded in 1916, the Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, the Endocrine Society's membership consists of over 18,000 scientists, physicians, educators, nurses and students in 122 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Washington, DC. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.

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