The first definitive summary of the best and safest blood pressure lowering treatments for kidney disease and diabetes patients has been compiled by New Zealand doctor and researcher Associate Professor Suetonia Palmer.
The international relevance of her work for doctors, patients and those who decide which drugs to fund has been demonstrated by the prestigious Lancet medical journal publishing an article on her study in its latest edition.
The University of Otago, Christchurch, researcher together with a global team used innovative statistical analysis to compare hundreds of research studies on the effectiveness of blood-pressure-lowering drugs for patients with kidney disease and diabetes. The result: a one-stop-shop, evidence-based guide on which drugs are safe and effective.
Diabetes and high blood pressure are the most common causes of kidney disease around the world, and people often have both. Chronic kidney disease caused by diabetes always affects both kidneys and generally gets worse over time, often leading to kidney failure requiring dialysis treatment or a kidney transplant.
Associate Professor Palmer says this study is important because diabetes and kidney disease are at epidemic proportions in New Zealand. A common treatment for those with diabetes and kidney disease is blood-pressure-lowering drugs. The aim of these drugs is to prevent kidney damage.
However, doctors and patients face a bewildering array of treatment options as there are many drugs available to lower blood pressure, many used in combination. There are also hundreds of research studies done on the effectiveness of drugs or combinations of drugs. It is not possible for people to identify the best available treatments without scientific advances such as this study.
Associate Professor Palmer works as a nephrologist, or kidney specialist, at the Canterbury District Health Board and commonly sees first-hand how confusing the wide range of treatment options can be for patients, and those who treat them.
Her paper is the first to compare all drug options, and combinations of commonly used drugs, against each other.
Associate Professor Palmer says it is thrilling to have her work recognised by one of the world's leading medical journals.
"It shows that we are producing research of international value at the University of Otago in Christchurch in collaboration with strong global partnerships."
The research published in the Lancet journal was funded by the Canterbury Medical Research Foundation.
Associate Professor Palmer also receives funding from the Royal Society as a Rutherford Discovery Fellow and the Health Research Council of New Zealand.
The research was done in collaboration with researchers at the Universities of Sydney, Ioannina, Copernicus, Calgary, Bari, Alberta, and Novara, and University College London. The Australian authors are Professor Jonathan Craig and Giovanni Strippoli, affiliated with the Sydney School of Public Health.