New Orleans, Louisiana - June 1, 2015 - Prevalence of a recently discovered serotype of oral bacterium, with a possible link to a number of systemic diseases, was found for the first time in a small cohort of African-American schoolchildren in a southwest Alabama town, according to research being presented at the annual meeting of the American Society for Microbiology.
Streptococcus mutans serotype k, first discovered in Japan in 2004, has been linked to a number of systemic diseases, including bacteremia, infective endocarditis and hemorrhagic stroke. "However, the bacteria evaluated in the present study were missing the proteins suggested to link S. mutans serotype k with these systemic diseases," said Stephanie Momeni, a doctoral candidate in the UAB Department of Biology, which is housed in UAB's College of Arts and Sciences and lead author of the study.
"S. mutans is associated with oral disease, but some serotypes have been reported to be more invasive and thus may also contribute to systemic disease," Momeni said. "The S. mutans serotype k found in this study has undetermined significance since it lacks the previously identified invasive genes. Given the small sample size, results are considered preliminary."
Samples were collected from schoolchildren between the ages of 5 and 10 as part of an ongoing longitudinal epidemiological study of S. mutans. A total of 57 children were tested with primers specific to each serotype and collagen-binding proteins. The study found serotypes c (84 percent), e (3 percent) and k (11 percent), with no serotype f observed. Two samples were untypeable.
Although the bacteria evaluated in this study were all missing the collagen-binding proteins suggested to link S. mutans serotype k and systemic disease, some scientists propose these genes may be acquired over time or that these organisms could have other unknown proteins possibly associated with systemic disease.
S. mutans is frequently associated with the formation of cavities. There are four known serotypes (c, e, f and k) that colonize humans, of which minor oral serotypes f and k are reported least often (less than 5 percent of the time). The purpose of this study was to determine the serotypes of 100 randomly selected S. mutans bacterial isolates and then determine whether these isolates possess two collagen-binding proteins, Cnm and Cbm, reportedly associated with systemic disease.
Momeni says further study is needed to determine if the S. mutans serotype k strains found in this study have other invasive qualities associated with systemic diseases. Furthermore, she adds, the prevalence of serotype k reported in this study may be conservative since only individual bacterial isolates were tested. This number could be considerably higher when more oral isolates are analyzed from each individual
The National Institute of Dental and Craniofacial Research provided research funding for the project.
Stephanie Momeni will participate in a media availability both live and online on Sunday, May 31, 2015 at 11:30 a.m. CDT. The availability will be broadcast from room 350 in the New Orleans Ernest N. Morial Convention Center and can be watched online at http://bit.
This research was presented as part of the 2015 General Meeting of the American Society for Microbiology held May 31- June 2, 2015 in New Orleans, Louisiana. A full press kit for the meeting, including tipsheets and additional press releases, can be found online at
The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.