Public Release: 

Experts present new knowledge on bone tissue and its role in bone strength or weakness

A collection of 8 invited reviews by leading researchers provides new insights into bone material properties, the various mineral, collagen and water compartments in bone, and the role of these properties in skeletal fragility

International Osteoporosis Foundation

Nyon, Switzerland - June 29, 2015 While there is good understanding of how bone mass, and more recently bone architecture, affects fracture risk, far less is known about the material properties of bone, or how these can impart resilience or fragility to the skeleton. This is changing thanks to the development of new state-of-the-art imaging and other technologies which now allow researchers to gain new insights into the different material properties of bone and their role in bone fragility.

Bringing together eight invited contributions by the field's leading experts, a special issue of Calcified Tissue International & Musculoskeletal Research now provides a comprehensive overview of the latest and most exciting findings in this area of skeletal research. The issue is co-edited by Drs. David B. Burr and Matthew R. Allen of the Department of Anatomy and Cell Biology, Indiana University School of Medicine.

Drs. Burr and Allen, the co-editors, challenged the authors not only to review the current state of knowledge about their specific topic, but to help propel research forward by highlighting key questions that remain to be addressed. "Our hope is that this will stimulate the new wave of work aimed at understanding both the hierarchical structure of bone and its importance to overall bone health."

Bone Material Properties and Skeletal Fragility - Foreword to Special Issue
David B. Burr, Matthew R. Allen
http://link.springer.com/article/10.1007/s00223-015-0012-7

Fragility of Bone Material Controlled by Internal Interfaces
Wolfgang Wagermaier, Klaus Klaushofer, Peter Fratzl
http://link.springer.com/article/10.1007/s00223-015-9978-4

Bone Material Properties and Skeletal Fragility
David P. Fyhrie, Blaine A. Christiansen
http://link.springer.com/article/10.1007/s00223-015-9997-1

The Role of Collagen Organization on the Properties of Bone
Patrick Garnero
http://link.springer.com/article/10.1007/s00223-015-9996-2

Effects of Collagen Crosslinking on Bone Material Properties in Health and Disease
Mitsuru Saito, Keishi Marumo
http://link.springer.com/article/10.1007/s00223-015-9985-5

Do Noncollagenous Proteins Affect Skeletal Mechanical Properties?
Stacyann Morgan, Atharva A. Poundarik, Deepak Vashishth
http://link.springer.com/article/10.1007/s00223-015-0016-3

The Mineral-Collagen Interface in Bone
Stuart R. Stock
http://link.springer.com/article/10.1007/s00223-015-9984-6

The Role of Water Compartments in the Material Properties of Cortical Bone
Mathilde Granke, Mark D. Does, Jeffry S. Nyman
http://link.springer.com/article/10.1007/s00223-015-9977-5

Bone's Material Constituents and their Contribution to Bone Strength in Health, Disease, and Treatment
Yohann Bala, Ego Seeman
http://link.springer.com/article/10.1007/s00223-015-9971-y

Professor René Rizzoli, journal Co Editor-in-Chief, stated, "We expect that this special issue will help provide a new understanding of the role of bone as a tissue, and how it contributes to skeletal integrity. This is an emerging area of research which is expected to have significant clinical relevance in the future."

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Calcified Tissue International & Musculoskeletal Research

This peer-reviewed journal publishes original preclinical, translational and clinical research, and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms, as well as clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions. NEW 2014 Impact Factor: 3.272 Link for Submissions http://www.editorialmanager.com/ctin/default.aspx

Editors in Chief: Stuart Ralston, René Rizzoli; Musculoskeletal Research Section Editor: Roger Fielding

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About IOF

The International Osteoporosis Foundation (IOF) is the world's largest nongovernmental organization dedicated to the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases. IOF members, including committees of scientific researchers, leading companies, as well as more than 200 patient, medical and research societies, work together to make bone, joint and muscle health a worldwide heath care priority. http://www.iofbonehealth.org; http://www.facebook.com/iofbonehealth; http://twitter.com/iofbonehealth

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