Cannabis -- marijuana, hashish -- was used as a go-to medical remedy by societies around the world for centuries. But the therapeutic use of marijuana was banned in most countries in the 1930s and '40s due to a growing awareness of the dangers of addiction. The significant medical benefits of marijuana in alleviating symptoms of such diseases as Parkinson's, cancer, and multiple sclerosis have only recently been reinvestigated.
A new study published in the Journal of Bone and Mineral Research by Tel Aviv University and Hebrew University researchers explores another promising new medical application for marijuana. According to the research, the administration of the non-psychotropic component cannabinoid cannabidiol (CBD) significantly helps heal bone fractures. The study, conducted on rats with mid-femoral fractures, found that CBD -- even when isolated from tetrahydrocannabinol (THC), the major psychoactive component of cannabis -- markedly enhanced the healing process of the femora after just eight weeks.
The research was led jointly by Dr. Yankel Gabet of the Bone Research Laboratory at the Department of Anatomy and Anthropology at TAU's Sackler Faculty of Medicine and the late Prof. Itai Bab of Hebrew University's Bone Laboratory.
Undeniable clinical potential
The same team, in earlier research, discovered that cannabinoid receptors within our bodies stimulated bone formation and inhibited bone loss. This paves the way for the future use of cannabinoid drugs to combat osteoporosis and other bone-related diseases.
"The clinical potential of cannabinoid-related compounds is simply undeniable at this point," said Dr. Gabet. "While there is still a lot of work to be done to develop appropriate therapies, it is clear that it is possible to detach a clinical therapy objective from the psychoactivity of cannabis. CBD, the principal agent in our study, is primarily anti-inflammatory and has no psychoactivity."
According to Dr. Gabet, our bodies are equipped with a cannabinoid system, which regulates both vital and non-vital systems. "We only respond to cannabis because we are built with intrinsic compounds and receptors that can also be activated by compounds in the cannabis plant," he said. The researchers found that the skeleton itself is regulated by cannabinoids. Even the addition of a non-psychogenic compound acting outside of the brain can affect the skeleton.
Separating the components out
"We found that CBD alone makes bones stronger during healing, enhancing the maturation of the collagenous matrix, which provides the basis for new mineralization of bone tissue," said Dr. Gabet. "After being treated with CBD, the healed bone will be harder to break in the future."
The researchers injected one group of rats with CBD alone and another with a combination of CBD and THC. After evaluating the administration of THC and CBD together in the rats, they found CBD alone provided the necessary therapeutic stimulus.
"We found CBD alone to be sufficiently effective in enhancing fracture healing," said Dr. Gabet. "Other studies have also shown CBD to be a safe agent, which leads us to believe we should continue this line of study in clinical trials to assess its usefulness in improving human fracture healing."
American Friends of Tel Aviv University supports Israel's most influential, most comprehensive, and most sought-after center of higher learning, Tel Aviv University (TAU). US News & World Report's Best Global Universities Rankings rate TAU as #148 in the world, and the Times Higher Education World University Rankings rank TAU Israel's top university. It is one of a handful of elite international universities rated as the best producers of successful startups, and TAU alumni rank #9 in the world for the amount of venture capital they attract.
A leader in the pan-disciplinary approach to education, TAU is internationally recognized for the scope and groundbreaking nature of its research and scholarship -- attracting world-class faculty and consistently producing cutting-edge work with profound implications for the future.