New Rochelle, NY, July 28, 2015-Results from a European clinical trial comparing therapeutic hypothermia to standard treatment for patients with elevated intracranial pressure (ICP) as a result of severe traumatic brain injury demonstrate a significant mean decrease in ICP with body cooling to 32-35oC, which did not occur in the absence of therapeutic hypothermia. The study design and preliminary data are reported in Therapeutic Hypothermia and Temperature Management, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Therapeutic Hypothermia and Temperature Management website until August 28, 2015.
Liam Flynn, BMBS, Jonathan Rhodes, MBChB, PhD, and Peter Andrews, MBChB, MD, University of Edinburgh and Western General Hospital, Edinburgh, UK, use a strategy of lowering the body temperature to affect increases in pressure and blood flow in and around the brain that cause much of the damage associated with traumatic brain injury. Among the patients with increased ICP in this study, who did not respond to initial therapy, a mean reduction in ICP of 4.3 + 1.6 mmHg was recorded at the first hour the target body temperature was reached, and the decrease in pressure continued throughout the 6 hours of hypothermia therapy.
The authors report the results in the article "Therapeutic Hypothermia Reduces Intracranial Pressure and Partial Brain Oxygen Tension in Patients with Severe Traumatic Brain Injury: Preliminary Data from the Eurotherm3235 Trial".
"These preliminary findings from an ongoing clinical trial are important to the field and support the beneficial effects of therapeutic hypothermia on controlling ICP elevations in severe TBI patients," says W. Dalton Dietrich, PhD, Editor-in-Chief and Kinetic Concepts Distinguished Chair in Neurosurgery, Professor of Neurological Surgery, Neurology and Cell Biology, University of Miami Leonard M. Miller School of Medicine.
About the Journal
Therapeutic Hypothermia and Temperature Management provides a multidisciplinary forum covering all aspects of hypothermia and temperature considerations relevant to this exciting field, including its application in cardiac arrest, spinal cord and traumatic brain injury, stroke, and burns. Novel findings from translational preclinical investigations as well as clinical studies and trials are featured in peer-reviewed articles, state-of-the-art review articles, provocative roundtable discussions, clinical protocols, and best practices. Tables of content and a sample issue may be viewed on the Therapeutic Hypothermia and Temperature Management website.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Journal of Neurotrauma and Brain Connectivity. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.