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Super graphene helps boost chemotherapy treatment

Replacing silver coating on catheters with graphene increases treatment effect

Norwegian University of Science and Technology

Chemotherapy treatment usually involves the patient receiving medicine through an intravenous catheter. These catheters, as well as the the equipment attached to them, are treated with a silver coating which is antibacterial, preventing bacterial growth and unwanted infections during a treatment.

Researchers at the Norwegian University of Science and Technology's (NTNU) Department of Physics are now studying what happens when different drugs come in contact with this silver coating.

Silver breaks down chemotherapy drugs

"We wanted to find potential problem sources in the tubes used in intravenous catheters. An interaction between the coating and the drugs was one possibility. Chemotherapy drugs are active substances, so it isn't hard to imagine that the medicine could react with the silver," says Justin Wells, an associate professor of physics at NTNU.

Wells and his students used x-ray photoemission spectroscopy (XPS) to look at the surface chemistry of one of the most commonly used chemotherapy drugs, 5-Fluorouracil (5-Fu), and the interaction between it and the type of silver coating found in medical equipment.

Using an XPS instrument at the synchrotron lab MAX IV in Sweden, they found that the antibacterial silver coating actually breaks down the drugs. Not only does this reduce the effect of a chemotherapy treatment, but it also creates hydrogen fluoride, a gas that can be harmful both to the patients and to the medical equipment.

"Reactions between chemotherapy drugs and other substances that the drugs come in contact with have, as far as we know, never been studied like this before," Wells says. It has always been assumed that the drugs reach the body fully intact.

Magical material

The group continued their studies with the XPS instrument, now examining how the same chemotherapy drugs reacted with graphene.

"Graphene is a non-reactive substance, and is sometimes referred to as a magical material that can solve any problem. So we thought that it might be a good combination with the chemotherapy drugs," Wells explains.

And they were right-- the drugs did not react with the graphene.

Graphene has already been suggested as a coating for medical equipment, and according to researchers, it should be possible to create thin layers of graphene designed for this use.

"This research has produced valuable information about the interaction between chemotherapy drugs and other substances that the medicine is in contact with. We hope that our work will contribute to making cancer treatment more effective, and that we can continue our work in this area. We would like to study the reaction between chemotherapy drugs and other substances and coatings used on medical equipment," Wells concludes.

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Reference: Graphene coatings for chemotherapy: avoiding silver-mediated degradation. Federico Mazzola, Thuat Trinh, Simon Cooil, Elise Ramleth Østli, Kristin Høydalsvik, Eirik Torbjørn Bakken Skjønsfjell, Signe Kjelstrup, Alexei Preobrajenski, Attilio A. Cafolla, D. Andrew Evans, Dag W. Breiby and Justin W.Wells. 2D Mater. 2 (2015) 025004. doi:10.1088/2053-1583/2/2/025004

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