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Modeling a nervous pathway involved in touch-induced behavior

PLOS

Many animals actively touch objects in their environment and respond to them by appropriate movement sequences. Jan Ache and Volker Dürr from Bielefeld University in Germany present a model in PLOS Computational Biology that captures key properties of a wide variety of descending neurons that are part of an "active touch system".

Goal-directed actions require neurons that descend from the brain to lower parts of the nervous system, for example: to distribute sensory information to local modules of movement control. Stick insects actively explore the near-range environment by means of sweeping feelers, and often respond to contacts of their feelers by directed reaching movements. This requires fast and multi-facetted information to be conveyed from the brain to the legs.

In their model Ache and Dürr propose how the nervous system can encode the movement of a tactile feeler in a small but diverse population of descending neurons. Their model is validated against the coding properties of real neurons by means of their location in what the authors call the "coding space". This coding space allows the description of a more complex set of response properties by two dimensions only. The immediate comparison of real and modeled neurons within the coding space allows both the systematic investigation of the model and the tuning of particular model variants as found in the real animal.

This is a first approach towards modeling an entire descending pathway that comprises very diverse neuron types within a single, common computational framework.

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All works published in PLOS Computational Biology are Open Access, which means that all content is immediately and freely available. Use this URL in your coverage to provide readers access to the paper upon publication: http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004263

Contact: Volker Dürr
Address: Bielefeld University
Biological Cybernetics, Faculty of Biology
Universitaetsstr.25
Bielefeld, D-33615
GERMANY
Phone: +49-521-1065528
Email: volker.duerr@uni-bielefeld.de

Citation: Ache JM, Dürr V (2015) A Computational Model of a Descending Mechanosensory Pathway Involved in Active Tactile Sensing. PLoS Comput Biol 11(7): e1004263. doi:10.1371/journal.pcbi.1004263

Funding: This work was supported by grant SP10, awarded to VD by the Cluster of Excellence 277 "Cognitive Interaction Technology" (CITEC), funded through the Deutsche Forschungsgemeinschaft. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

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