Public Release: 

Exercise may be associated with reduced disease activity in children with MS

American Academy of Neurology

MINNEAPOLIS - A new study suggests children with multiple sclerosis (MS) who exercise regularly may have a less active disease. The research is published in the August 12, 2015, online issue of Neurology®, the medical journal of the American Academy of Neurology.

"Up to three-quarters of children with MS experience depression, tiredness, or memory and thinking impairment," said study author E. Ann Yeh, MD, with The Hospital for Sick Children (SickKids) in Toronto, Associate Professor at the University of Toronto in Toronto, Ontario, Canada and a member of the American Academy of Neurology. "Our research is important since little is known regarding how lifestyle behaviors may affect the disease."

For the study, 31 children with MS and 79 who had experienced a single inflammatory neurologic event were given questionnaires about tiredness, depression and how often they exercised. Of those, 60 were also given MRI brain scans to measure brain volume and the amount and type of MS lesions they had.

Only 45 percent of the children with MS reported participating in any strenuous physical activity, compared to 82 percent of the other children. The children with MS who took part in strenuous physical activity were more likely to have a lower overall volume (amount) of lesions in the brain that indicate disease activity, or T2 lesions, than the children with MS who did not do strenuous activity. Those who did strenuous activity had a median of 0.46 cm3 of T2 lesions, compared to 3.4 cm3 for those with no strenuous activity. Also, those with strenuous activity had a median of 0.5 relapses per year, compared to 1 per year for those with no strenuous activity. The children with MS also had higher levels of tiredness and depression compared to the other children studied. There were no differences in whole brain volumes. The results were the same after researchers adjusted for the severity of the children's disease.

"These findings add to the possibility that physical activity may have a beneficial effect on the health of the brain," said Yeh.

Yeh noted that the study does not determine a cause-and-effect relationship between physical activity and disease activity in MS, but only shows an association between the two.


The study was supported by the MS Society of Canada, Canadian Multiple Sclerosis Scientific Research Foundation and SickKids Foundation.

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The American Academy of Neurology, an association of more than 28,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson's disease and epilepsy.

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