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Queen's leads €50 million program to develop new antibiotics for cystic fibrosis and bronchiectasis

Researchers at Queen's University Belfast are leading a €50 million, Europe-wide, project to develop new drug treatments that could improve the lives of patients with cystic fibrosis and bronchiectasis

Queen's University Belfast

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IMAGE: Professor Stuart Elborn is the Dean of the School of Medicine, Dentistry and Biomedical Sciences at Queen's University. view more

Credit: Queen's University Belfast

Researchers at Queen's University Belfast are leading a €50 million, Europe-wide, project to develop new drug treatments that could improve the lives of patients with cystic fibrosis and bronchiectasis.

The iABC (inhaled Antibiotics in Bronchiectasis and Cystic Fibrosis) consortium, which is made up of world-leading lung specialists from across Europe, will develop new 'inhaled antibiotics' to manage chronic lung infection, the main cause of disease and death in patients with cystic fibrosis and bronchiectasis.

The new antibiotics, which are to be trialed over a five year period and are being developed in response to an urgent need for new forms of inhaled antibiotics, are expected to improve patients' quality of life by reducing lung infections and flare ups, improving lung function, and overcoming antibacterial resistance which frequently occurs in patients with these conditions.

The programme will also establish the first European patient register for bronchiectasis, providing a platform to improve the quality of care for patients across Europe, as well as making it easier to develop and trial new drugs.

The Consortium, which is led by researchers from the School of Medicine, Dentistry and Biomedical Sciences, and the School of Pharmacy, at Queen's University, with EFPIA partners Novartis and Basilea, is funded by the European Commission through the Innovative Medicines Initiative (IMI) and involves researchers from 20 organisations in eight countries across Europe. The Belfast Health and Social Care Trust will be a key partner in clinical trials of the new antibiotics.

Professor Stuart Elborn, Dean of the School of Medicine, Dentistry and Biomedical Sciences at Queen's University, and Lead Researcher on the project, said: "There are limited antibiotics available to treat lung infection in cystic fibrosis and bronchiectasis, and the bacteria causing them are becoming increasingly resistant to current antibiotics. To ensure the development of new drug types we are bringing together world leading researchers with proven expertise in antibiotic development, clinical trials, and high-quality research.

"This work has the potential to deliver inhaled antibiotics that will improve the quality of life and survival of cystic fibrosis and bronchiectasis patients. It is the latest example of the commitment of researchers and staff at Queen's University to advancing knowledge and changing lives by working with international experts."

Queen's Vice-Chancellor, Professor Patrick Johnston said: "Northern Ireland and Queen's University are leading the way in developing new treatments for chronic lung diseases. The work of Professor Elborn and his colleagues is already making a huge different to thousands of people living with these conditions. Today's funding announcement will ensure that this life-changing and life-saving research will continue."

The development of the iABC-consortium has been supported by the Northern Ireland Contact Point (NICP) for Health, based in the Research and Enterprise Directorate at Queen's and the Health and Social Care Research and Development Division of the Public Health Agency.

The Northern Ireland Contact Point (NICP) network, established to provide support to EC funding applicants, is funded by Northern Ireland's Department of Employment and Learning (DEL) and Department of Enterprise, Trade and Investment (DETI).

Employment and Learning Minister Dr Stephen Farry said: "I commend Queen's on successfully securing €23.3 million from the Innovative Medicines Initiative (IMI). This award will facilitate world leading collaborative research to develop new antibiotic treatment options for people with cystic fibrosis and bronchiectasis.

"I am pleased that the Northern Ireland Contact Point (NICP) for Health, funded through the DEL-DETI Higher Education EU Framework Support Programme, played a substantial role in securing this funding. The NICP network provides specialist advice and assistance to academics and businesses across areas of economic relevance to Northern Ireland and of priority to the European Commission."

Enterprise, Trade and Investment Minister, Jonathan Bell, said: "I want to congratulate Queen's University on this tremendous success in Horizon 2020 which will see over €23m come to Northern Ireland. Securing these major international research awards is an important part of the NI Executive's Innovation Strategy to transform our economy into one that is knowledge based. The University's success is not only testimony to the world class research capabilities we have in Northern Ireland but also to the support provided by the Department of Enterprise, Trade and Investment and the Department for Employment and Learning though the Horizon 2020 Northern Ireland Contact Point Network which played a key part in helping secure this research award?."

Dr Janice Bailie, Assistant Director, HSC R&D Division, Public Health Agency said: "This significant award builds on a long track record of world-leading research led by Professor Elborn and his team in Northern Ireland, in collaboration with international partners in Europe and the United States. HSC R&D Division is proud to have supported this research group over the last 15 years, a period that has seen their work contribute to major improvements to the lives of people with cystic fibrosis. I am delighted that our continued support and partnership with the team has helped them secure this award to carry out further research in this important area."

The iABC consortium involves researchers from the UK, Spain, Germany, France, Italy, Belgium, the Netherlands and Switzerland.

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Media inquiries to Anne-Marie Clarke (Mon-Wed) or Michelle Cassidy (Thurs-Fri) Queen's University Communications Office +44(0)28 9097 5320 / 5310 email comms.officer@qub.ac.uk

Notes to editors:

Professor Stuart Elborn, Dean of the School of Medicine, Dentistry and Biomedical Sciences at Queen's University, is available for interview. Interviews bids to Queen's Communications Office (contact details above).

Cystic fibrosis (CF) is a genetic disease that blocks a person's lungs and digestive system, affecting approximately 36,000 people in the European Union. More than 95% of deaths in patients with CF are due to respiratory failure. Bronchiectasis (BE) is a group of diseases in which a person's airways become damaged and scarred. In developed countries, BE affects from 4 per 100 000 young adults to nearly 300 per 100,000 persons 75 years and older.

Organisations involved in the iABC consortium are: Queen's University Belfast, Belfast Health and Social Care Trust, University Medical Center Utrecht, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Hannover, Rijksuniversiteit Groningen, Servicio Madrileño de Salud, Madrid, Universitair Ziekenhuis Antwerpen, University of Dundee, Institut National de la Santé et de la Recherche, Poitiers, Università degli Studi di Milano, Hospices Civils de Lyon, Medizinische Hochschule Hannover, Universiteit Antwerpen, University of Edinburgh, Royal Brompton and Harefield NHS Foundation Trust, Fundació Clínic per a la Recerca Biomèdica, Barcelona, Papworth Hospital NHS Foundation Trust, Erasmus Medical Center, Rotterdam, Basilea Pharmaceutica International Ltd, and Novartis Pharma AG, Basel.

IMI and ND4BB: In November 2011, the European Commission launched its Action Plan against the rising threat from Antimicrobial Resistance, and called for 'unprecedented collaborative research and development efforts to bring new antibiotics to patients.' The New Drugs for Bad Bugs (ND4BB) program was launched within the Innovative Medicine initiative (IMI) in direct response to this call. IMI is a joint undertaking between the European Union and the European Federation of Pharmaceutical Industries and Associations (EFPIA). It constitutes Europe's largest public-private initiative aiming to accelerate the development of better and safer medicines for patients. Find out more at http://www.imi.europa.eu

EFPIA: Brings together 33 European national pharmaceutical industry associations as well as 40 leading companies undertaking research, development and the manufacture in Europe of medicinal products for human use. Find out more at http://www.efpia.eu/

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