Public Release: 

Which dermal fillers 'stick together' best? New method helps plastic surgeons choose the best product

Wolters Kluwer Health

September 28, 2015 - With booming interest in dermal fillers for minimally invasive treatment of facial lines and wrinkles, plastic surgeons are looking for evidence to help them choose the product that will give the best results for their patients. A new, validated method for providing standard ratings of cohesivity for currently available hyaluronic acid (HA) gel fillers is reported in the October issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

The pilot study was conducted by Dr. Hema Sundaram, a dermatologist in Rockville, Md.; Samuel Gavard Molliard, a scientist in Geneva, Switzerland; and colleagues. Ratings of cohesivity and other biophysical properties are important not for identifying the single "best" filler, but rather for choosing the product best suited to each procedure being performed.

Data on Cohesivity Can Guide Choice of Dermal Fillers

Injection of dermal fillers is rapidly increasing in popularity. Fillers are used to reduce facial lines and wrinkles; and restore volume, fullness and a youthful shape to the face, among other purposes. According to ASPS statistics, dermal filler injection is one of the most common minimally invasive cosmetic procedures, with 2.3 million procedures performed in 2014. In the US alone, the value of the filler market is more than $1 billion, based on statistics from the Cosmetic Surgery National Data Bank and other market research.

Hyaluronic acid dermal fillers are most commonly used because they are natural, gel-based products that are highly compatible with the body. A wide range of HA fillers are available, and plastic surgeons try to match their individual properties to the purposes for which they will be used. But there's a lack of scientific data to support this matching process, including the rheologic (flow-related) properties of the various available products.

One key property is cohesivity, defined as the capacity of a material not to dissociate--in other words, how well it "sticks together." "Cohesivity...maintains gel integrity, contributes to tissue support with natural contours, and diminishes surface irregularities," Dr. Sundaram and coauthors write.

The researchers developed a standard test for comparing the cohesivity of HA dermal fillers. Samples of each filler gel were dyed, then squeezed into water and stirred using automated technology. A panel of plastic surgeon and dermatologist specialists experienced in using HA fillers then rated each sample's cohesivity on an original five-point scale, known as the Gavard-Sundaram scale.

On testing of six FDA-approved fillers, cohesivity scores varied across the full range of the scale: from "fully dispersed" to "fully cohesive." Cohesivity was rated high for one product, medium to high for three, low to medium for one, and low for one.

But that doesn't mean that products with higher cohesivity scores are always the best. Rather, the goal of the ranking system is to "provide a scientific rationale for the intuitive selection of different products for specific clinical objectives"--in other words, to help plastic surgeons choose the filler with properties that are most suited to the precise purpose for which it is being used.

For example, fillers with higher cohesivity may be a better choice for more superficial placement, or placement in mobile areas such as around the mouth or eyes. Products with lower cohesivity may be effective for use as "deep volumizers", according to Dr. Sundaram and coauthors.

The researchers believe that having comparative data on cohesivity--as well as other rheologic properties, such as elasticity and viscosity--is an advance that can make dermal filler procedures more sophisticated and successful. This information will be increasingly useful as new FDA approvals increase the availability and variety of filler products.


Click here to read "Cohesivity of Hyaluronic Acid Fillers: Development and Clinical Implications of a Novel Assay, Pilot Validation with a Five-Point Grading Scale, and Evaluation of Six U.S. Food and Drug Administration-Approved Fillers."

Article: "Cohesivity of Hyaluronic Acid Fillers: Development and Clinical Implications of a Novel Assay, Pilot Validation with a Five-Point Grading Scale, and Evaluation of Six U.S. Food and Drug Administration-Approved Fillers" (doi: 10.1097/PRS.0000000000001638)

Plastic and Reconstructive Surgery® is published by Wolters Kluwer.

About Plastic and Reconstructive Surgery

For more than 60 years, Plastic and Reconstructive Surgery® ( has been the one consistently excellent reference for every specialist who uses plastic surgery techniques or works in conjunction with a plastic surgeon. The official journal of the American Society of Plastic Surgeons, Plastic and Reconstructive Surgery® brings subscribers up-to-the-minute reports on the latest techniques and follow-up for all areas of plastic and reconstructive surgery, including breast reconstruction, experimental studies, maxillofacial reconstruction, hand and microsurgery, burn repair, and cosmetic surgery, as well as news on medico-legal issues.

About ASPS

The American Society of Plastic Surgeons (ASPS) is the world's largest organization of board-certified plastic surgeons. Representing more than 7,000 Member Surgeons, the Society is recognized as a leading authority and information source on aesthetic and reconstructive plastic surgery. ASPS comprises more than 94 percent of all board-certified plastic surgeons in the United States. Founded in 1931, the Society represents physicians certified by The American Board of Plastic Surgery or The Royal College of Physicians and Surgeons of Canada. ASPS advances quality care to plastic surgery patients by encouraging high standards of training, ethics, physician practice and research in plastic surgery. You can learn more and visit the American Society of Plastic Surgeons at or and

About Wolters Kluwer

Wolters Kluwer is a global leader in professional information services. Professionals in the areas of legal, business, tax, accounting, finance, audit, risk, compliance and healthcare rely on Wolters Kluwer's market leading information-enabled tools and software solutions to manage their business efficiently, deliver results to their clients, and succeed in an ever more dynamic world.

Wolters Kluwer reported 2014 annual revenues of €3.7 billion. The group serves customers in over 170 countries, and employs over 19,000 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands. Wolters Kluwer shares are listed on NYSE Euronext Amsterdam (WKL) and are included in the AEX and Euronext 100 indices. Wolters Kluwer has a sponsored Level 1 American Depositary Receipt program. The ADRs are traded on the over-the-counter market in the U.S. (WTKWY).

Wolters Kluwer Health is a leading global provider of information and point of care solutions for the healthcare industry. For more information about our products and organization, visit, follow @WKHealth or @Wolters_Kluwer on Twitter, like us on Facebook, follow us on LinkedIn, or follow WoltersKluwerComms on YouTube.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.