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Effects of traumatic injury and disease on functional brain networks examined in brain connectivity

Mary Ann Liebert, Inc./Genetic Engineering News

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IMAGE: Brain Connectivity is the essential peer-reviewed journal covering groundbreaking findings in the rapidly advancing field of connectivity research at the systems and network levels. Published 10 times per year online... view more

Credit: ©Mary Ann Liebert, Inc., publishers

New Rochelle, NY, October 14, 2015--New research clearly shows that injury, disease, and related therapeutic interventions can impact critical crosstalk and connectivity between functional networks and brain regions. The effects of traumatic brain injury (TBI), stroke, and repetitive brain stimulation are among the topics examined in articles published in the Injury and Disease special issue of Brain Connectivity, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The issue is available free on the Brain Connectivity website until November 14, 2015.

In "Investigation of Information Flow During a Novel Working Memory Task in Individuals with Traumatic Brain Injury," Ekaterina Dobryakova and coauthors from Kessler Foundation (West Orange, NJ), Rutgers New Jersey Medical School (Newark, NJ), and the Department of Veterans Affairs' War Related Illness & Injury Study Center (East Orange, NJ), used a novel tool called CapMan to assess brain connectivity and information flow associated with working memory across brain hemispheres. The results of their study showed hyper-connectivity and less coherent information flow in TBI patients compared to healthy individuals.

Ying-Chia Lin, et al. from University of Verona (Italy), Ecole Polytechnique Féderale de Lausanne, University of Geneva, University of Lausanne, and Siemens Schweiz AG (Switzerland) demonstrated that after a stroke, which causes oxygen deprivation and ischemic damage to brain tissue in one brain hemisphere, remodeling of neuronal axons and myelin takes place not only in the injured motor network, but through connectivity plasticity, also in the uninjured motor network in the other hemisphere. The researchers present their findings in the article "Quantitative Analysis of Myelin and Axonal Remodeling in the Uninjured Motor Network After Stroke."

The article "Effect of Repetitive Transcranial Magnetic Stimulation on fMRI Resting-State Connectivity in Multiple System Atrophy" describes a noninvasive stimulatory intervention that delivers repeated magnetic pulses to treat neurological and psychiatric conditions. Ying-hui Chou and colleagues from Duke University Medical Center (Durham, NC), and Peking Union Medical College Hospital (Beijing, China), studied the effects of this treatment method on resting-state brain functional networks and the relationship to changes in motor symptoms in patients with multiple system atrophy (MSA). Compared to MSA patients given a sham treatment, those treated with repetitive transcranial magnetic stimulation showed significant improvement in motor positive changes in several aspects of related functional brain connectivity.

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Research reported in the above noted publications was supported by the National Institutes of Health under Award Numbers 1R42NS050007-02 and R01-NS074045. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About the Journal

Brain Connectivity is the essential peer-reviewed journal covering groundbreaking findings in the rapidly advancing field of connectivity research at the systems and network levels. Published 10 times per year online with open access options and in print, the Journal is under the leadership of Founding and Co-Editors-in-Chief Christopher Pawela, PhD, Assistant Professor, Medical College of Wisconsin, and Bharat Biswal, PhD, Chair of Biomedical Engineering, New Jersey Institute of Technology. It includes original peer-reviewed papers, review articles, point-counterpoint discussions on controversies in the field, and a product/technology review section. To ensure that scientific findings are rapidly disseminated, articles are published Instant Online within 72 hours of acceptance, with fully typeset, fast-track publication within 4 weeks. Tables of content and a sample issue may be viewed on the Brain Connectivity website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative medical and biomedical peer-reviewed journals, including Journal of Neurotrauma and Therapeutic Hypothermia and Temperature Management. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, newsmagazines, and books is available on the Mary Ann Liebert, Inc., publishers website.

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