A new study, published in the open access journal Genome Biology, has identified a single gene (TLE6) which, when mutated, is responsible for human embryonic lethality at an earlier stage of development than has ever previously been documented.
Many genetic mutations exist which are fatal to developing embryos, but identifying them can be difficult, especially in the earliest stages of embryonic development. Identifying the genetic mutations responsible for embryo lethality provides new insights into the biological processes underlying embryonic development, and could also potentially lead to improved fertility treatments, by allowing scientists to screen and identify unviable embryos before implantation as part of IVF treatment.
Researchers from Alfaisal University and King Faisal Specialist Hospital and Research Centre, Saudi Arabia worked with two consanguineous families, where a marriage has taken place within the same family, in which several women were having persistent difficulties conceiving after IVF treatment. Using gene sequencing to study the embryos conceived by these women, the researchers found that a mutation in a single gene (TLE6) was halting the development of embryos at a very early stage.
Around one in seven people worldwide live in communities with consanguineous marriages, which is particularly common in North Africa, the Middle East and West Asia. In consanguineous marriages, there is often an increased prevalence of homozygous recessive genotypes. This makes the effects and characteristics of these genotypes much easier to identify and study, allowing researchers to gain new insights into genetic development.
Although previous studies have worked with consanguineous families to identify genes responsible for embryonic lethality in the late first trimester and beyond, this is the first study to pinpoint a gene which works in the earliest stages of embryonic development at the pre-implantation stage. Although the mechanism by which mutation in TLE6 stops embryonic development is not clear, the results show that the identified mutation in the maternal effect gene TLE6, which encodes a component of the sub-cortical maternal complex, impairs binding to other components of this complex. These results are supported by available data from mouse models in which deficiency of the individual components of the sub-cortical maternal complex results in an arrest at very early stages of embryonic development. The researchers suggest that mutations in TLE6 and other components of the subcortical maternal complex may be an under recognized cause of female infertility in humans.
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1. Research article
TLE6 Mutation Causes the Earliest Known Human Embryonic Lethality
Anas M Alazami, Salma M. Awad, Serdar Coskun, Saad Al-Hassan4, Hadia Hijazi, Firdous M Abdulwahab, Coralie Poizat, Fowzan S Alkruaya
Genome Biology 2015
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